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Abstract：
Thrombophilia is an important cause of recurrent spontaneous abortion (RSA). The treatment of thrombophilia is beneficial to the prevention of RSA. Therefore, we explored the clinical effect of Chinese traditional herbs with the effects of invigorating the blood, tonifying the kidney and calming the fetus in the treatment of RSA complicated with thrombophilia. We retrospectively analyzed the clinical outcomes of 190 RSA patients combined with thrombophilia using different treatment methods. The traditional Chinese medicine group was treated with kidney-invigorating, blood-activating and fetus-soothing herbs and the western medicine group was treated with low molecular weight heparin (LMWH), and the traditional Chinese medicine combined with western medicine group was treated with LMWH plus Chinese traditional herbs with the effects of kidney tonifying, blood activating and fetus stabilizing. After treatments, platelet aggregation rate, plasma D-dimer and uterine artery blood flow resistance were significantly reduced in the LMWH plus herbs compared to the simple herbs and LMWH group (P < 0.0167). The LMWH plus herbs group significantly accelerated the growth of fetal bud compared with other groups (P < 0.0167). Moreover, the LMWH plus herbs group improved traditional Chinese medicine syndrome scores (P < 0.0167), showing a better clinical efficacy. Adverse reactions occurred in five patients in the LMWH group but not in the simple herbs and LMWH plus herbs group during the treatment period. Therefore, our study shows that for the treatment of RSA complicated with thrombophilia, Chinese traditional herbs plus LMWH can improve the blood supply of the uterus during pregnancy and contribute to a favorable environment for the growth of the fetus. Chinese traditional herbs exert a good curative effect with few adverse reactions.
摘要：
血栓形成是复发性自然流产(RSA)的重要缘由。血栓性疾病的治疗有利于RSA的预防。因此,我们探讨了补血中药的临床疗效，补肾镇静治疗RSA合并血栓形成倾向。回顾性分析190例RSA合并血栓性疾病患者采用不同治疗方法的临床转归。中药组采用补肾法治疗,活血疏胎中药和西药组用低分子肝素(LMWH)治疗,中药联合西药组用LMWH加中药补肾,血液激活和胎儿稳定。治疗后,血小板聚集率，与单纯中药和LMWH组相比，LMWH组的血浆D-二聚体和子宫动脉血流阻力显着降低（P<0.0167）。与其他组相比，LMWH加中药组明显加快了胎儿芽的生长（P<0.0167）。此外，LMWH加中药组改善中医证候积分(P<0.0167),显现出较好的临床疗效。在治疗期间，LMWH组中有5例患者发生了不良反应，但在简单草药和LMWH加草药组中没有发生不良反应。因此,我们的研究表明，对于RSA合并血栓形成的治疗，中草药加LMWH可以改善怀孕期间子宫的血液供应，并为胎儿的生长提供有利的环境。中药具有良好的疗效，不良反应少。
