关键词: Acetylcholine provocation testing Case report Catamenial vasospasm Menstruation NSTEMI Vasospasm Women’s Health

来  源:   DOI:10.1093/ehjcr/ytad019   PDF(Pubmed)

Abstract:
UNASSIGNED: Coronary artery spasm is an established mechanism of myocardial infarction with non-obstructive coronary arteries (MINOCA). Various mechanisms have been proposed, ranging from vascular smooth muscle hyperreactivity to endothelial dysfunction, to autonomic nervous system dysregulation.
UNASSIGNED: We report a case of a 37-year-old woman who presented with recurrent non-ST elevation myocardial infarction (NSTEMI), coinciding with her menstrual periods. Intracoronary acetylcholine provocation testing resulted in coronary spasm in the left anterior descending artery (LAD) that was relieved with nitroglycerine. Initiating calcium channel blockade and suppressing cyclical variation in sex hormones resulted in improvement of her symptoms and cessation of monthly NSTEMI events due to coronary spasm.
UNASSIGNED: Initiating calcium channel blockade and suppressing cyclical variation in sex hormones resulted in improvement of her symptoms and cessation of monthly NSTEMI events due to coronary spasm. Catamenial coronary artery spasm is a rare, but clinically important, presentation of myocardial infarction with non-obstructive coronary arteries (MINOCA).
摘要:
未经证实:冠状动脉痉挛是非阻塞性冠状动脉心肌梗死(MINOCA)的既定机制。已经提出了各种机制,从血管平滑肌高反应性到内皮功能障碍,自主神经系统失调.
未经证实:我们报告了一例37岁女性复发性非ST段抬高型心肌梗死(NSTEMI),与她的月经周期相吻合。冠状动脉内乙酰胆碱激发试验导致左前降支(LAD)的冠状动脉痉挛,硝化甘油缓解了冠状动脉痉挛。启动钙通道阻滞和抑制性激素的周期性变化可改善她的症状,并停止因冠状动脉痉挛引起的每月NSTEMI事件。
UNASSIGNED:启动钙通道阻断和抑制性激素的周期性变化可改善患者的症状,并停止因冠状动脉痉挛引起的每月NSTEMI事件。月经性冠状动脉痉挛是一种罕见的,但是临床上很重要,表现为非阻塞性冠状动脉心肌梗死(MINOCA)。
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