METHODS: One hundred and ninety-seven patients were involved in the training cohort to develop a new prognostic score to predict the overall survival (OS) of brain metastases for specific primary tumors. Independent prognostic factors were confirmed using a Cox regression model. The score was developed based on clinical prognostic factors of OS with Cox proportional hazards model. The result was validated in another cohort with 56 participants to evaluate the performance of the score.
RESULTS: One hundred and ninety-seven patients with 329 brain metastases received SRT. For NSCLC, the significant prognostic factors were extracranial metastases, target therapy and number of brain metastases. For gastrointestinal cancer, the significant prognostic factors were target therapy and number of brain metastases.
CONCLUSIONS: The prognostic factors scores were varied by the histologic types which can be used to efficiently stratify for selected patients with brain-metastasis.
方法:共有一百九十七名患者参与训练队列,以制定新的预后评分来预测特定原发肿瘤的脑转移的总生存期(OS)。
结果:一百九十七例329例脑转移患者接受了SRT。
结论:预后因子评分因组织学类型而异,可用于对选定的脑转移患者进行有效分层。