Abstract:
Patients with inflammatory bowel disease often experience ongoing pain even after achieving mucosal healing (i.e., post-inflammatory pain). Factors related to the brain-gut axis, such as peripheral and central sensitization, altered sympatho-vagal balance, hypothalamic-pituitary-adrenal axis activation, and psychosocial factors, play a significant role in the development of post-inflammatory pain. A comprehensive study investigating the interaction between multiple predisposing factors, including clinical psycho-physiological phenotypes, molecular mechanisms, and multi-omics data, is still needed to fully understand the complex mechanism of post-inflammatory pain. Furthermore, current treatment options are limited and new treatments consistent with the underlying pathophysiology are needed to improve clinical outcomes.
摘要:
炎症性肠病患者即使在实现粘膜愈合后也经常经历持续的疼痛(即,炎症后疼痛)。与脑-肠轴相关的因素,如外周和中枢致敏,交感神经-迷走神经平衡改变,下丘脑-垂体-肾上腺轴激活,和社会心理因素,在炎症后疼痛的发展中起重要作用。一项综合研究,调查多个诱发因素之间的相互作用,包括临床心理生理表型,分子机制,和多组数据,仍然需要充分了解炎症后疼痛的复杂机制。此外,目前的治疗方案有限,需要与基础病理生理学相一致的新疗法来改善临床结局.