{Reference Type}: Journal Article
{Title}: Post-inflammatory Abdominal Pain in Patients with Inflammatory Bowel Disease During Remission: A Comprehensive Review.
{Author}: Takahashi K;Khwaja IG;Schreyer JR;Bulmer D;Peiris M;Terai S;Aziz Q;
{Journal}: Crohns Colitis 360
{Volume}: 3
{Issue}: 4
{Year}: Oct 2021
暂无{DOI}: 10.1093/crocol/otab073
{Abstract}: Patients with inflammatory bowel disease often experience ongoing pain even after achieving mucosal healing (i.e., post-inflammatory pain). Factors related to the brain-gut axis, such as peripheral and central sensitization, altered sympatho-vagal balance, hypothalamic-pituitary-adrenal axis activation, and psychosocial factors, play a significant role in the development of post-inflammatory pain. A comprehensive study investigating the interaction between multiple predisposing factors, including clinical psycho-physiological phenotypes, molecular mechanisms, and multi-omics data, is still needed to fully understand the complex mechanism of post-inflammatory pain. Furthermore, current treatment options are limited and new treatments consistent with the underlying pathophysiology are needed to improve clinical outcomes.