Abstract：
Endometriosis of the cervix is a rare form of genital endometriosis, which is characterized by the appearance of tissue on the vaginal part of the cervix, similar to the tissue of the mucous membrane of the uterine cavity. We describe a clinical case in which we compared the content of cytoskeletal proteins, H3 histone modifications and DNA methylation (total and 5-hydroxymethylcytosine content) in the eutopic endometrium and in tissue from endometriosis foci on the cervix. The patient had elevated levels of estradiol, interleukin-1β and interleukin-8. At the cellular level, the content of tubulin and the marker of stable microtubules were reduced in the ectopic endometrium (by 45% and 37%, p < 0.05, respectively), but the alpha-actinin-1 content was increased (by 75%, p < 0.05) with an increase in the expression of its gene. At the same time, the total level of DNA methylation in the endometriotic focus was reduced by more than 2 times with the accumulation of the intermediate product 5-hydroxymethylcytosine (the content increased by more than 3 times), probably due to an increase in the content of tet methylcytosine dioxygenase 1 (more than 4 times).
摘要：
子宫颈子宫内膜异位症是一种罕见的生殖器子宫内膜异位症，其特征是宫颈阴道部分的组织外观，类似于子宫腔粘膜的组织。我们描述了一个临床病例，其中我们比较了细胞骨架蛋白的含量，在位子宫内膜和子宫颈子宫内膜异位症病灶组织中的H3组蛋白修饰和DNA甲基化（总和5-羟甲基胞嘧啶含量）。病人的雌二醇水平升高，白细胞介素-1β和白细胞介素-8。在细胞层面,在异位子宫内膜中，微管蛋白的含量和稳定微管的标记物减少（减少了45％和37％，p分别<0.05)，但是α-肌动蛋白-1的含量增加了(75%，p<0.05），其基因表达增加。同时,随着中间产物5-羟甲基胞嘧啶的积累，子宫内膜异位病灶中DNA甲基化的总水平降低了2倍以上（含量增加了3倍以上），可能是由于tet甲基胞嘧啶双加氧酶1的含量增加（超过4倍）。
