PDF(Pubmed)
Abstract：
Localized scleroderma is an inflammatory disease causing sclerosis of the skin. The aetiology and pathogenesis of localized scleroderma remain unclear. Localized scleroderma is considered a genetically driven disease. It is not well understood if genetic factors or environmental exposure individually can cause its development or if their interaction is needed to trigger the disease. Some authors postulate that familial clustering is evidence of a hereditary disease. Familial localized scleroderma has been rarely reported and is a case worth studying. We present the review of literature on this subject with 3 additional cases of familial localized scleroderma with paediatric onset.
摘要：
局部硬皮病是引起皮肤硬化的炎性疾病。局限性硬皮病的病因和发病机制尚不清楚。局限性硬皮病被认为是遗传驱动的疾病。尚不清楚遗传因素或环境暴露是否单独导致其发展，或者是否需要它们的相互作用来引发疾病。一些作者假设家族聚集是遗传性疾病的证据。家族性局限性硬皮病鲜有报道，值得研究。我们对这一主题的文献进行了综述，其中又有3例家族性局限性硬皮病伴儿科发作。
