Abstract：
The Polylactide membrane (PLM) is a biosynthetic dressing that mimics properties of the human epithelium. Herein we describe our experience on the use of PLM in pediatric burns. All pediatric burn patients admitted to the Pediatric Surgery Department between November 2019 and November 2021 and submitted to PLM application were selected. Clinical and demographic data were collected retrospectively. Seventy-seven patients with a median age of 1.8 years were included. The median total body surface area was 6% (2-20%), and burns were mainly mixed-partial thickness. PLM was applied at a median of 5 days post-burn (IQR 3-6), usually under sedation (43/77). After PLM application, the median healing time (HT) was 10 days (IQR 8-14). HT was significantly higher in deep-partial thickness burns vs. mixed superficial-deep (P = .015) and superficial burn areas (P = .006). No correlation was found between HT and the timing of PLM application. The grafting rate due to clinical misevaluation was 2.7%, one infection was found. The PLM is a promising way for treating partial-thickness burns, even when applied later during treatment. Shorter HT, the decreased need for dressing changes, and the potential of sparing of donor sites and pain reduction are its main advantages.
摘要：
聚乳酸膜(PLM)是模拟人上皮特性的生物合成敷料。在此，我们描述了我们在小儿烧伤中使用PLM的经验。选择2019年11月至2021年11月期间入住小儿外科并提交PLM申请的所有小儿烧伤患者。回顾性收集临床和人口统计学数据。包括77例中位年龄为1.8岁的患者。平均体表面积为6%（2-20%），烧伤主要是混合局部厚度。在烧伤后5天的中位数应用PLM（IQR3-6），通常处于镇静状态（43/77）。聚乳酸膜应用后，中位愈合时间（HT）为10天（IQR8-14）。深部分厚度烧伤的HT明显高于混合浅层深度（p=.015）和浅层烧伤区域（p=.006）。在HT和聚乳酸膜应用的时机之间没有发现相关性。由于临床误判导致的移植率为2.7%，发现了一种感染。聚乳酸膜是治疗部分厚度烧伤的一种有前途的方法，即使在以后的治疗过程中使用。缩短愈合时间，更换敷料的需求减少，保留供体部位和减轻疼痛的潜力是其主要优势。
