关键词: Fluorescence Fluorescence laparoscope Indocyanine green Lymph node dissection Oesophageal cancer

Mesh : Middle Aged Humans Male Indocyanine Green Esophageal Squamous Cell Carcinoma / diagnostic imaging surgery etiology Quality of Life Photochemotherapy / methods Photosensitizing Agents Esophageal Neoplasms / diagnostic imaging surgery Laparoscopy / adverse effects methods Optical Imaging / methods Fluorescence

来  源:   DOI:10.1016/j.pdpdt.2023.103325

Abstract:
BACKGROUND: Surgery remains the main primary treatment for non-advanced oesophageal cancer. Conventional thoracotomy and laparotomy can result in severe trauma, slow recovery, more complications, low quality of life, and reduced survival outcomes. Laparoscopic surgery has reduced the above-mentioned problems. However, some challenges remain associated with this approach, such as lymphadenectomy, anastomotic leakage, and inadequate surgical margins. Near-infrared fluorescence (NIRF) imaging using indocyanine green (ICG) in combination with laparoscopic surgery, provides real-time navigation throughout the entire surgical procedure.
METHODS: A middle-aged male patient presented to our health centre with progressive dysphagia for > 2 months. Endoscopy and biopsy revealed oesophageal squamous cell carcinoma 34 cm from the incisors (tumour node metastasis classification (TNM) T3N1M0 IIIB). ICG imaging fluorescence laparoscopic surgery was successfully performed to complete the oesophagectomy and oesophageal and tubular stomach anastomosis by accurately locating the lesion, retaining adequate upper and lower margins, visually dissecting the lymph nodes, and testing the anastomotic blood supply. The postoperative TNM stage was T2N0M0 ⅡA. The patient recovered quickly without complications. Postoperative chemotherapy was administered. After three years of follow-up, the patient had no recurrence or complications.
CONCLUSIONS: Fluorescence laparoscopy provides an excellent surgical treatment modality for patients with oesophageal cancer.
摘要:
背景:手术仍是非晚期食管癌的主要治疗方法。传统的开胸和剖腹手术会导致严重的创伤,恢复缓慢,更多的并发症,生活质量低,和降低生存结果。腹腔镜手术减少了上述问题。然而,这种方法仍然存在一些挑战,比如淋巴结清扫术,吻合口漏,手术切缘不足。使用吲哚菁绿(ICG)结合腹腔镜手术进行近红外荧光(NIRF)成像,在整个手术过程中提供实时导航。
方法:一名中年男性患者因进行性吞咽困难2个月到我们的健康中心就诊。内窥镜检查和活检显示距离切牙34厘米的食管鳞状细胞癌(肿瘤淋巴结转移分类(TNM)T3N1M0IIIB)。ICG成像荧光腹腔镜手术成功完成食管切除及食管管状胃吻合,准确定位病灶,保持足够的上下边缘,在视觉上解剖淋巴结,并测试吻合口的血液供应。术后TNM分期为T2N0M0ⅡA。患者恢复迅速,无并发症。术后给予化疗。经过三年的随访,患者无复发或并发症。
结论:荧光腹腔镜为食管癌患者提供了一种极好的手术治疗方式。
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