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Abstract：
Hypertrophic cardiomyopathy (HCM) is the most common heart disease in cats. Electrocardiographic (ECG) analysis can help with the diagnosis of HCM and also in the investigation of the secondary consequences of the disease. This study investigated ECG markers of QT interval variability (total instability [TI], short-term instability [STI], long-term instability [LTI], QT variance [QTv]), mean QT interval (QTa) and QT interval corrected for heart rate (QTac), as well as the duration (QRSd) and dispersion (QRSv) of the QRS interval in healthy cats and in those with HCM.
Data were collected from 63 domestic cats: 40 in the control group and 23 in the HCM group. Fifty consecutive QT intervals were recorded for all cats and then QTa, QTac, QTv, TI, LTI and STI were calculated. QRSd and QRSv were also obtained for all animals. A Mann-Whitney U-test was used for group comparison. Receiver operating characteristic curves were plotted to evaluate the sensitivity and specificity of all markers for HCM. Logistic regression analysis was performed to assess the risks of cats having HCM, based on the studied indexes.
QTa (P <0.01), QTac (P <0.01), QRSd (P <0.01) and STI (P = 0.02) were higher in the HCM group. QTa >158.8 ms, QTac >27.4 ms and QRSd >0.045 s had an accuracy of 77.4%, 68.2% and 80.9%, respectively, in detecting HCM. Logistic regression showed that cats with QTa >158 ms, QTac >27.4 ms and QRSd >0.045 s had a 1.58-, 1,23- and 6.5-fold higher risk, respectively, of developing HCM.
Cats with HCM had higher ventricular instability as assessed by STI and showed a prolongation of the QT and QRS intervals via the QTa, QTac and QRSd markers. These markers show potential as ancillary screening tools for identifying the presence of HCM.
Data were collected from 63 domestic cats: 40 in the control group and 23 in the HCM group. Fifty consecutive QT intervals were recorded for all cats and then QTa, QTac, QTv, TI, LTI and STI were calculated. QRSd and QRSv were also obtained for all animals. A Mann-Whitney U-test was used for group comparison. Receiver operating characteristic curves were plotted to evaluate the sensitivity and specificity of all markers for HCM. Logistic regression analysis was performed to assess the risks of cats having HCM, based on the studied indexes.
QTa (P <0.01), QTac (P <0.01), QRSd (P <0.01) and STI (P = 0.02) were higher in the HCM group. QTa >158.8 ms, QTac >27.4 ms and QRSd >0.045 s had an accuracy of 77.4%, 68.2% and 80.9%, respectively, in detecting HCM. Logistic regression showed that cats with QTa >158 ms, QTac >27.4 ms and QRSd >0.045 s had a 1.58-, 1,23- and 6.5-fold higher risk, respectively, of developing HCM.
Cats with HCM had higher ventricular instability as assessed by STI and showed a prolongation of the QT and QRS intervals via the QTa, QTac and QRSd markers. These markers show potential as ancillary screening tools for identifying the presence of HCM.
摘要：
目的：肥厚型心肌病（HCM）是猫中最常见的心脏病。心电图（ECG）分析可以帮助诊断HCM，也有助于研究疾病的继发后果。本研究调查了QT间期变异性的心电图标志物(总不稳定性[TI]，短期不稳定[STI]，长期不稳定[LTI]，QT方差[QTv])，平均QT间期（QTa）和经心率校正的QT间期（QTac），以及健康猫和HCM猫QRS间期的持续时间（QRSd）和离散度（QRSv）。
方法:从63只家猫收集数据:对照组40只,HCM组23只。记录所有猫的50个连续QT间隔，然后记录QTa，QTac,QTv,TI,计算LTI和STI。还获得了所有动物的QRSd和QRSv。使用Mann-WhitneyU检验进行组比较。绘制受试者工作特征曲线以评估所有标志物对HCM的敏感性和特异性。进行Logistic回归分析以评估猫患有HCM的风险，根据研究的指标。
结果：QTa（P<0.01），QTac(P<0.01),HCM组QRSd（P<0.01）和STI（P=0.02）较高。QTa>158.8ms,QTac>27.4ms和QRSd>0.045s的准确度为77.4%，68.2%和80.9%，分别,检测HCM。Logistic回归显示QTa>158ms的猫，QTac>27.4ms和QRSd>0.045s具有1.58-，风险增加1.23倍和6.5倍，分别,开发HCM。
结论：通过STI评估，患有HCM的猫具有更高的心室不稳定性，并通过QTa显示QT和QRS间期延长，QTac和QRSd标记。这些标记物显示出作为鉴定HCM存在的辅助筛选工具的潜力。
方法:从63只家猫收集数据:对照组40只,HCM组23只。记录所有猫的50个连续QT间隔，然后记录QTa，QTac,QTv,TI,计算LTI和STI。还获得了所有动物的QRSd和QRSv。使用Mann-WhitneyU检验进行组比较。绘制受试者工作特征曲线以评估所有标志物对HCM的敏感性和特异性。进行Logistic回归分析以评估猫患有HCM的风险，根据研究的指标。
结果：QTa（P<0.01），QTac(P<0.01),HCM组QRSd（P<0.01）和STI（P=0.02）较高。QTa>158.8ms,QTac>27.4ms和QRSd>0.045s的准确度为77.4%，68.2%和80.9%，分别,检测HCM。Logistic回归显示QTa>158ms的猫，QTac>27.4ms和QRSd>0.045s具有1.58-，风险增加1.23倍和6.5倍，分别,开发HCM。
结论：通过STI评估，患有HCM的猫具有更高的心室不稳定性，并通过QTa显示QT和QRS间期延长，QTac和QRSd标记。这些标记物显示出作为鉴定HCM存在的辅助筛选工具的潜力。
