Data were collected from 63 domestic cats: 40 in the control group and 23 in the HCM group. Fifty consecutive QT intervals were recorded for all cats and then QTa, QTac, QTv, TI, LTI and STI were calculated. QRSd and QRSv were also obtained for all animals. A Mann-Whitney U-test was used for group comparison. Receiver operating characteristic curves were plotted to evaluate the sensitivity and specificity of all markers for HCM. Logistic regression analysis was performed to assess the risks of cats having HCM, based on the studied indexes.
QTa (P <0.01), QTac (P <0.01), QRSd (P <0.01) and STI (P = 0.02) were higher in the HCM group. QTa >158.8 ms, QTac >27.4 ms and QRSd >0.045 s had an accuracy of 77.4%, 68.2% and 80.9%, respectively, in detecting HCM. Logistic regression showed that cats with QTa >158 ms, QTac >27.4 ms and QRSd >0.045 s had a 1.58-, 1,23- and 6.5-fold higher risk, respectively, of developing HCM.
Cats with HCM had higher ventricular instability as assessed by STI and showed a prolongation of the QT and QRS intervals via the QTa, QTac and QRSd markers. These markers show potential as ancillary screening tools for identifying the presence of HCM.
方法:从63只家猫收集数据:对照组40只,HCM组23只。记录所有猫的50个连续QT间隔,然后记录QTa,QTac,QTv,TI,计算LTI和STI。还获得了所有动物的QRSd和QRSv。使用Mann-WhitneyU检验进行组比较。绘制受试者工作特征曲线以评估所有标志物对HCM的敏感性和特异性。进行Logistic回归分析以评估猫患有HCM的风险,根据研究的指标。
结果:QTa(P<0.01),QTac(P<0.01),HCM组QRSd(P<0.01)和STI(P=0.02)较高。QTa>158.8ms,QTac>27.4ms和QRSd>0.045s的准确度为77.4%,68.2%和80.9%,分别,检测HCM。Logistic回归显示QTa>158ms的猫,QTac>27.4ms和QRSd>0.045s具有1.58-,风险增加1.23倍和6.5倍,分别,开发HCM。
结论:通过STI评估,患有HCM的猫具有更高的心室不稳定性,并通过QTa显示QT和QRS间期延长,QTac和QRSd标记。这些标记物显示出作为鉴定HCM存在的辅助筛选工具的潜力。