Abstract：
BACKGROUND: Several randomized clinical trials showed that aspirin could decrease the incidence of preeclampsia (PE) in women at high risk, but data from sources other than traditional clinical trials that investigating the preventive effect of aspirin 75 mg on PE is still lacking, especially in mainland China. We aimed to use Chinese real-world data to estimate the preventive effect of low-dose aspirin (LDA) on PE.
METHODS: Clinical data of pregnant women who were at high risk of PE and had their first prenatal visit at the affiliated Taicang People\'s Hospital of Soochow University during November 31, 2018 and May 10, 2021 was retrospectively analyzed. Among the 266 included pregnant women, 115 individuals treated with aspirin 75 mg per day and the other 151 without such treatment were considered as the LDA group and the control group, respectively.
RESULTS: In the LDA group, 64 (55.65%) of 115 pregnant women took aspirin before 16 weeks of gestation. Besides, 12 (10.43%) and 34 (22.52%) women developed PE in the LDA group and control group, respectively; the aspirin prophylaxis was associated with a lower risk of PE (odds ratio = 0.40, 95% confidence interval = 0.20-0.82, P = 0.0098). In addition, LDA is slightly more effective when initiated before 16 weeks of gestation or in those without chronic hypertension, when compared with their counterparts.
CONCLUSIONS: Prophylaxis with 75 mg per day of aspirin in high-risk women resulted in a significantly lower incidence of PE than that in the control group.
METHODS: Clinical data of pregnant women who were at high risk of PE and had their first prenatal visit at the affiliated Taicang People\'s Hospital of Soochow University during November 31, 2018 and May 10, 2021 was retrospectively analyzed. Among the 266 included pregnant women, 115 individuals treated with aspirin 75 mg per day and the other 151 without such treatment were considered as the LDA group and the control group, respectively.
RESULTS: In the LDA group, 64 (55.65%) of 115 pregnant women took aspirin before 16 weeks of gestation. Besides, 12 (10.43%) and 34 (22.52%) women developed PE in the LDA group and control group, respectively; the aspirin prophylaxis was associated with a lower risk of PE (odds ratio = 0.40, 95% confidence interval = 0.20-0.82, P = 0.0098). In addition, LDA is slightly more effective when initiated before 16 weeks of gestation or in those without chronic hypertension, when compared with their counterparts.
CONCLUSIONS: Prophylaxis with 75 mg per day of aspirin in high-risk women resulted in a significantly lower incidence of PE than that in the control group.
摘要：
背景：一些随机临床试验表明，阿司匹林可以降低高危女性先兆子痫（PE）的发生率，但是，除了传统的临床试验之外，研究阿司匹林75毫克对PE的预防作用的数据仍然缺乏，尤其是在中国大陆。我们旨在使用中国的实际数据来评估低剂量阿司匹林（LDA）对PE的预防作用。
方法：回顾性分析2018年11月31日和2021年5月10日在苏州大学附属太仓市人民医院进行首次产前检查的PE高危孕妇的临床资料。在266名孕妇中，115名每天服用阿司匹林75mg的患者，另外151名没有服用阿司匹林的患者作为LDA组和对照组，分别。
结果：在LDA组中，115名孕妇中有64名（55.65%）在妊娠16周前服用阿司匹林。此外,在LDA组和对照组中，有12名（10.43％）和34名（22.52％）女性患有PE，分别;阿司匹林预防与PE风险降低相关(比值比=0.40,95%置信区间=0.20-0.82,P=0.0098).此外,LDA在妊娠16周前开始时或在没有慢性高血压的患者中稍微更有效。与他们的同行相比。
结论：高危女性每天服用75mg阿司匹林的预防导致PE的发生率明显低于对照组。
方法：回顾性分析2018年11月31日和2021年5月10日在苏州大学附属太仓市人民医院进行首次产前检查的PE高危孕妇的临床资料。在266名孕妇中，115名每天服用阿司匹林75mg的患者，另外151名没有服用阿司匹林的患者作为LDA组和对照组，分别。
结果：在LDA组中，115名孕妇中有64名（55.65%）在妊娠16周前服用阿司匹林。此外,在LDA组和对照组中，有12名（10.43％）和34名（22.52％）女性患有PE，分别;阿司匹林预防与PE风险降低相关(比值比=0.40,95%置信区间=0.20-0.82,P=0.0098).此外,LDA在妊娠16周前开始时或在没有慢性高血压的患者中稍微更有效。与他们的同行相比。
结论：高危女性每天服用75mg阿司匹林的预防导致PE的发生率明显低于对照组。
