Abstract：
The clinical symptoms and signs of methamphetamine-associated psychosis (MAP) and schizophrenia are highly similar, but the situation is completely different when MAP and schizophrenia patients need to be assessed for criminal responsibility after they comitted a harmful behavior. Therefore, the distinction between the two psychoses is very important in forensic psychiatry. At present, the identification of these two psychoses is mainly dependent on the corresponding criteria such as the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and the Chinese Classification of Mental Disorders Version 3 (CCMD-3). It\'s challenging to diagnose and distinguish between the two in practical cases due to their similar clinical symptoms and the lack of effective objective indexes. Different from the limitations of single omics, integrative omics intergrates data from multiple dimensions and has been extensively studied in the field of schizophrenia and has achieved some preliminary results. In view of the correlation between MAP and schizophrenia and the potential application value of integrative omics, this paper proposes an integrative omics strategy for MAP pathogenesis and forensic identification, aiming to improve the further understanding of the relationship between the two psychoses and the corresponding pathogenesis. It also provides references for the future exploration of integrative omics in forensic precise identification and effective monitoring and early warning methods.
甲基苯丙胺所致精神障碍（methamphetamine-associated psychosis，MAP）和精神分裂症的临床症状及体征十分相似，但MAP和精神分裂症患者在发生危害行为后需评定刑事责任时的情况却完全不同，因而两者的甄别在法医精神病学鉴定中十分重要。目前对于两者的鉴别主要依据《精神障碍诊断与统计手册（第五版）》《中国精神障碍分类与诊断标准（第三版）》等诊断标准，但由于两者高度相似的临床表现和客观指标的缺乏，给法医学鉴识实践工作带来了很大的困难和挑战。不同于单一组学的局限性，整合组学将多个维度的数据整合起来，已在精神分裂症领域开展了广泛研究并初步取得一些应用成果。鉴于MAP和精神分裂症的关联性和整合组学的潜在的应用价值，本文提出以整合组学的策略进行MAP发病机制及法医学鉴识的研究思路，旨在完善对MAP与精神分裂症之间的关系及相应发病机制的进一步理解，也为未来整合组学在法医学精准鉴识及有效监测预警方法的探索提供借鉴与参考。.
甲基苯丙胺所致精神障碍（methamphetamine-associated psychosis，MAP）和精神分裂症的临床症状及体征十分相似，但MAP和精神分裂症患者在发生危害行为后需评定刑事责任时的情况却完全不同，因而两者的甄别在法医精神病学鉴定中十分重要。目前对于两者的鉴别主要依据《精神障碍诊断与统计手册（第五版）》《中国精神障碍分类与诊断标准（第三版）》等诊断标准，但由于两者高度相似的临床表现和客观指标的缺乏，给法医学鉴识实践工作带来了很大的困难和挑战。不同于单一组学的局限性，整合组学将多个维度的数据整合起来，已在精神分裂症领域开展了广泛研究并初步取得一些应用成果。鉴于MAP和精神分裂症的关联性和整合组学的潜在的应用价值，本文提出以整合组学的策略进行MAP发病机制及法医学鉴识的研究思路，旨在完善对MAP与精神分裂症之间的关系及相应发病机制的进一步理解，也为未来整合组学在法医学精准鉴识及有效监测预警方法的探索提供借鉴与参考。.
摘要：
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