PDF(Pubmed)
Abstract：
Sensitive skin (SS) is a common cutaneous condition that seriously affects people\'s quality of life, but studies of sensitive skin pathogenesis are unclear, the exploration are ongoing, and the biophysical properties of sensitive skin disagree with the study results. In this paper, we summarize the noninvasive biophysical and imaging instrumental methods used for sensitive skin and provide support for the classification of sensitive skin subtypes to prescribe precise treatment. PubMed and Web of Science databases were searched according to PRISMA guidelines for articles from January 1971 to May 2022 that used noninvasive biophysical or imaging methods to monitor adult subjects with sensitive skin. The quality of the included articles was determined based on 22 items of the STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) statement. A total of 55 studies were included, representing 8 biophysical and 5 imaging methods and their applications in treatment efficacy evaluation studies. The biophysical parameter and cutaneous morphological property changes in sensitive skin subjects were observed. The quality of the studies was relatively low, and there was high variability in results between studies. Several parameters have shown tremendous potential in exploring the pathogenesis with different sensitive skin subtypes: type I may be detected with higher transepidermal water loss and lower stratum corneum hydration values, as well as with thinner epidermis with a shallower and more irregular honeycomb structure; Type II and III are more prone to higher blood flow, lower current perception threshold than normal skin. This systematic review identifies key reasons for the lack of uniform trends in noninvasive measurements and recommends the use of effective selection instruments or relevant parameters to explore the pathogenesis of sensitive skin, and to differentiate the subtypes of sensitive skin for achieving the precise treatment.
摘要：
敏感性皮肤(SS)是一种常见的皮肤疾病,严重影响人们的生活质量,但是敏感皮肤发病机制的研究尚不清楚，探索正在进行中，敏感皮肤的生物物理特性与研究结果不一致。在本文中,我们总结了用于敏感皮肤的非侵入性生物物理和成像仪器方法，并为敏感皮肤亚型的分类提供支持，以制定精确治疗方案。根据PRISMA指南，从1971年1月至2022年5月检索PubMed和WebofScience数据库，这些文章使用非侵入性生物物理或成像方法监测具有敏感皮肤的成年受试者。纳入文章的质量是根据加强流行病学观察研究报告（STROBE）声明的22项确定的。共纳入55项研究，代表8种生物物理和5种成像方法及其在治疗疗效评估研究中的应用。观察敏感皮肤受试者的生物物理参数和皮肤形态特性变化。研究的质量相对较低，研究之间的结果差异很大。几个参数在探索不同敏感皮肤亚型的发病机理方面显示出巨大的潜力：I型可以检测到更高的经皮水分流失和更低的角质层水合值，以及更薄的表皮，更浅和更不规则的蜂窝结构;II和III型更容易出现更高的血流量，电流感知阈值低于正常皮肤。本系统综述确定了无创测量缺乏统一趋势的关键原因，并建议使用有效的选择工具或相关参数来探索敏感皮肤的发病机理。并区分敏感皮肤的亚型，以实现精确的治疗。
