PDF(Pubmed)
Abstract：
Triosephosphate isomerase (TPI) is best known as a glycolytic enzyme that interconverts the 3-carbon sugars dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P). TPI is an essential enzyme that is required for the catabolism of DHAP and a net yield of ATP from anaerobic glucose metabolism. Loss of TPI function results in the recessive disease TPI Deficiency (TPI Df). Recently, numerous lines of evidence suggest the TPI protein has other functions beyond glycolysis, a phenomenon known as moonlighting or gene sharing. Here we review the numerous functions ascribed to TPI, including recent findings of a nuclear role of TPI implicated in cancer pathogenesis and chemotherapy resistance.
摘要：
磷酸三糖异构酶（TPI）是最著名的糖酵解酶，可将3碳糖磷酸二羟丙酮（DHAP）和甘油醛-3-磷酸（G3P）相互转化。TPI是DHAP分解代谢和来自厌氧葡萄糖代谢的ATP净产量所需的必需酶。TPI功能的丧失导致隐性疾病TPI缺乏(TPIDf)。最近,大量证据表明TPI蛋白具有糖酵解以外的其他功能，一种被称为月光或基因共享的现象。在这里，我们回顾了归因于TPI的众多功能，包括最近发现TPI在癌症发病机制和化疗耐药中的核作用。
