SMARCB1(INI-1)-Deficient Sinonasal Carcinoma: An Evolving Entity.

SMARCB1 （ INI - 1 ） 缺陷性鼻窦癌 ： 一个进化实体。

• 发表时间: Jan 2023
• 来源期刊: J Neurol Surg Rep
• DOI: 10.1055/a-1996-1283
• PMID: 36712411
• 文章类型: Case Reports
• 作者列表: Chung SY,Kenee P,Mitton T,Halderman A

关键词: EZH2; INI-1; SMARCB1; SMARCB1(INI-1)-deficient; SNUC; SWI/SNF; SWItch/Sucrose non-fermentable; sinonasal carcinoma; sinonasal undifferentiated carcinoma

Abstract

SMARCB1(INI-1)-deficient sinonasal carcinoma is a rare, poorly differentiated neoplasm with a poor prognosis. Though historically most were identified as sinonasal undifferentiated carcinoma, we now understand it to be a distinct entity. There is currently a general consensus supporting multimodal therapy, though the optimal sequence of surgery, chemotherapy, and radiation has yet to be defined.

摘要

SMARCB1（INI-1）缺陷型鼻腔鼻窦癌是一种罕见的，低分化肿瘤预后差。尽管历史上大多数被确定为鼻窦未分化癌，我们现在理解它是一个独特的实体。目前有一个普遍的共识支持多模式治疗，虽然手术的最佳顺序，化疗,辐射尚未定义。