PDF(Pubmed)
Abstract：
UNASSIGNED: The gut microbiota is associated with risk for colorectal cancer (CRC), a chronic disease for which racial disparities persist with Black Americans having a higher risk of CRC incidence and mortality compared to other groups. Given documented racial differences, the gut microbiota may offer some insight into previously unexplained racial disparities in CRC incidence and mortality. A case-control analysis comparing 11 women newly diagnosed with CRC with 22 cancer-free women matched on age, BMI, and race in a 1:2 ratio was conducted. Information about participants\' diet and perceived stress levels were obtained via 24-hour Dietary Recall and Perceived Stress Scale-10 survey, respectively. Participants provided stool samples from which microbial genomic DNA was extracted to reveal the abundance of 26 genera chosen a priori based on their previously observed relevance to CRC, anxiety symptoms, and diet.
UNASSIGNED: Significantly lower alpha diversity was observed among cancer-free Black women compared to all other race-cancer status combinations. No group differences were observed when comparing beta diversity. Non-Hispanic White CRC cases tended to have higher relative abundance of Fusobacteria, Gemellaceae, and Peptostreptococcus compared to all other race-cancer combination groups. Perceived stress was inversely associated with alpha diversity and was associated with additional genera.
UNASSIGNED: Our findings suggest that microbiome-CRC associations may differ by racial group. Additional large, racially diverse population-based studies are needed to determine if previously identified associations between characteristics of the gut microbiome and CRC are generalizable to Black women and other racial, ethnic, and gender groups.
UNASSIGNED: Significantly lower alpha diversity was observed among cancer-free Black women compared to all other race-cancer status combinations. No group differences were observed when comparing beta diversity. Non-Hispanic White CRC cases tended to have higher relative abundance of Fusobacteria, Gemellaceae, and Peptostreptococcus compared to all other race-cancer combination groups. Perceived stress was inversely associated with alpha diversity and was associated with additional genera.
UNASSIGNED: Our findings suggest that microbiome-CRC associations may differ by racial group. Additional large, racially diverse population-based studies are needed to determine if previously identified associations between characteristics of the gut microbiome and CRC are generalizable to Black women and other racial, ethnic, and gender groups.
摘要：
背景肠道菌群与结直肠癌（CRC）的风险相关，一种种族差异持续存在的慢性疾病,与其他人群相比,美国黑人患CRC的风险和死亡率更高.鉴于记录在案的种族差异，肠道微生物群可能有助于了解以前无法解释的CRC发病率和死亡率的种族差异.一项病例对照分析比较了11名新诊断为CRC的女性与22名年龄相匹配的无癌女性，BMI,并以1:2的比例进行比赛。通过24小时饮食召回和感知压力量表-10调查获得了有关参与者饮食和感知压力水平的信息，分别。参与者提供了粪便样本，从中提取了微生物基因组DNA，以揭示根据先前观察到的与CRC的相关性先验选择的26个属的丰度。焦虑症状,和饮食。结果与所有其他种族-癌症状态组合相比，无癌黑人女性的α多样性明显较低。比较β多样性时未观察到组差异。非西班牙裔白人CRC病例倾向于具有较高的镰刀菌相对丰度，双子科,和肽链球菌与所有其他种族-癌症组合组的比较。感知压力与α多样性成反比，并与其他属相关。结论我们的研究结果表明，微生物组-CRC关联可能因种族而异。额外的大，需要进行种族多样性的基于人群的研究，以确定先前确定的肠道微生物组特征与CRC之间的关联是否可推广到黑人妇女和其他种族，民族,和性别群体。
