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Abstract：
Primary cutaneous B-cell lymphomas (PCBCLs) are very rare to be seen in pediatric and adolescent age group, especially primary cutaneous follicle center lymphoma (PCFCL) which is considered the least occurring main subtype. Here, we describe a 16-year-old girl who developed a slowly growing solitary firm smooth surfaced erythematous nodule over her forearm. Histopathological examination showed a dense dermal nodular, periadnexal and perivascular lymphoid infiltrate extending deep to the subcutis. Immunohistochemical staining showed a B-cell population with positivity for CD20, variable staining for BCL6 and CD10 and uniquely staining for BCL2. Although a primary cutaneous marginal zone lymphoma (PCMZL) was considered but the presences of interfollicular BCL6 and CD10 positivity established the diagnosis of PCFCL. To our knowledge, only 12 cases of pediatric and adolescent PCFCL have been described in the literature.
摘要：
原发性皮肤B细胞淋巴瘤（PCBCLs）在儿童和青少年年龄组中非常罕见，尤其是原发性皮肤滤泡中心淋巴瘤（PCFCL），被认为是发生最少的主要亚型。这里,我们描述了一个16岁的女孩，她的前臂上出现了一个缓慢增长的孤立的坚硬光滑表面红斑结节。组织病理学检查显示真皮致密结节，附件周围和血管周围淋巴浸润，延伸至皮下组织。免疫组织化学染色显示B细胞群具有CD20阳性、BCL6和CD10可变染色和BCL2独特染色。尽管考虑了原发性皮肤边缘区淋巴瘤（PCMZL），但滤泡间BCL6和CD10阳性的存在确立了PCFCL的诊断。据我们所知,文献中仅描述了12例儿童和青少年PCFCL.
