RESULTS: A retrospective study of 157 subjects from a single university fertility center from January 2017 to March 2020, was performed. All patients stimulated with FD for IUI were included. The number of failed, normal, or overstimulation cycles was determined based on stimulating not more than 2 mature follicles. We then stratified the group based on the AFC, AMH, and body weight. Of 157 subjects, 49% stimulated correctly, 5.6% failed and 45.4% overstimulated. An analysis of the COH IUI cycles based on stratification and over or lack of stimulation per published guidelines found that women with a bodyweight < 80 kg or AMH ≥ 1.5 ng/ml or AFC ≥ 10 initially stimulate with FD 2.0 to 3.0mcg daily. For women with an AFC of 6-9 stimulate with Follitropin Delta 3.0mcg daily. For women with an AFC < 6 or serum AMH < 1.5 ng/ml stimulate with FD 3.0-4.0mcg daily. For women with body weight > 80 kg stimulate initially with daily with 4.0-6.0mcg FD.
CONCLUSIONS: Follitropin Delta can be used safely for controlled ovarian stimulation and insemination at doses easily dispensed by the current methods of delivery, within the current published guidelines for follicle development.
结果:从2017年1月至2020年3月,对来自单一大学生育中心的157名受试者进行了回顾性研究。包括所有因IUI而受到FD刺激的患者。失败的次数,正常,基于刺激不超过2个成熟卵泡来确定或过度刺激周期。然后我们根据AFC对小组进行分层,AMH,和体重。157个科目中,49%正确刺激,5.6%失败,45.4%过度刺激。根据已发布的指南,基于分层和过度或缺乏刺激的COHIUI周期分析发现,体重<80kg或AMH≥1.5ng/ml或AFC≥10的女性最初每天以FD2.0至3.0mcg刺激。对于AFC为6-9的女性,每天用FollitropinDelta3.0mcg刺激。对于AFC<6或血清AMH<1.5ng/ml的女性,每天用FD3.0-4.0mcg刺激。对于体重>80公斤的女性,最初每天以4.0-6.0mcgFD进行刺激。
结论:FollitropinDelta可以安全地用于控制性卵巢刺激和授精,其剂量可以通过当前的分娩方法轻松分配,在目前公布的卵泡发育指南中。