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Abstract：
Campylobacter species are among the aetiological agents responsible for 400-500 million human diarrhoea cases per annum. The risk of dissemination of antibiotic-resistant Campylobacter species between humans, animals, and the environment is anticipated, given its transmissibility through these sources. The objective of this paper is to present a situation analysis that reports the current patterns and determinants of Campylobacter antibiotic resistance in South Africa. This review applies the One Health (OH) Approach to systematically review and collate the current antibiotic resistance status among Campylobacter spp. in South Africa. The highest level of resistance of Campylobacter in humans is to azithromycin (69.7%), whereas the lowest level of resistance of Campylobacter is to gatifloxacin (8.3%). In animals, high resistance to common antibiotics erythromycin (95.06%), clindamycin (95.68%), doxycycline (87.65%), erythromycin (90%), tetracycline (84.3%), streptomycin (88%), and ampicillin (73%) while 100% resistance of Campylobacter from water samples to tetracycline, imipenem, is recorded. Furthermore, resistance to clarithromycin (95%), azithromycin (92%), clindamycin (84.2%), doxycycline (80%), and ciprofloxacin (77.8%) is reported among Campylobacter spp. from water samples. The genetic similarity results suggest the movement of antibiotic-resistant Campylobacter spp. between humans and the environment. More research on antibiotic resistance among Campylobacter from other sources, outside clinical isolates, is recommended.
摘要：
弯曲杆菌是每年造成400-500万例人类腹泻病例的病原体之一。抗生素抗性弯曲杆菌在人类之间传播的风险，动物,环境是可以预期的，考虑到它通过这些来源的可传播性。本文的目的是提供一种情况分析，以报告南非弯曲杆菌抗生素耐药性的当前模式和决定因素。这篇综述应用一种健康（OH）方法来系统地回顾和整理弯曲杆菌属的抗生素耐药性现状。在南非。人体弯曲杆菌的耐药性最高的是阿奇霉素(69.7%),而弯曲杆菌对加替沙星的耐药水平最低(8.3%)。在动物中,对常见抗生素红霉素的高耐药性（95.06%），克林霉素（95.68%），多西环素（87.65%），红霉素（90％），四环素（84.3%），链霉素（88%），和氨苄青霉素（73％），而水样中的弯曲杆菌对四环素的耐药性为100％，亚胺培南,被记录下来。此外，对克拉霉素的耐药性（95％），阿奇霉素（92%），克林霉素（84.2%），多西环素（80%），弯曲杆菌中报告了环丙沙星（77.8％）。从水样。遗传相似性结果表明抗生素抗性弯曲杆菌的运动。在人类和环境之间。更多关于其他来源的弯曲杆菌抗生素耐药性的研究，在临床分离株之外，是推荐的。
