PDF(Pubmed)
Abstract：
UNASSIGNED: Social stress in adolescents precipitates stress-related emotional disorders. In this study we aimed to investigate oligodendrogenesis in three stress-associated brain regions, medial prefrontal cortex (mPFC), habenula, and amygdala in adolescent mice exposed to social defeat stress.
UNASSIGNED: Four-week-old adolescent mice were subjected to social defeat for 10 days, followed by behavioral tests and evaluations of oligodendroglial proliferation and differentiation.
UNASSIGNED: Stressed mice showed reduced social interaction, more stretched approach posture, lower sucrose preference, but no changes in the forced swimming test. EdU labeled proliferative cells, newly formed NG2+EdU + oligodendrocyte precursor cells (OPCs), and Olig2+EdU+ oligodendrocyte lineage cells (OLLs) were significantly decreased in the mPFC and the lateral habenula, but not in the amygdala and the medial habenula in socially defeated mice. APC+Edu+ newly-generated mature oligodendrocytes (OLs) were decreased in the mPFC in stressed mice. However, the total number of NG2+ OPCs, APC+ mature OLs, and Olig2+ OLLs were comparable in all the brain regions examined between stressed and control mice except for a decrease of APC+ mature OLs in the prelimbic cortex of stressed mice.
UNASSIGNED: Our findings indicate that adolescent social stress causes emotion-related behavioral changes and region-specific impairment of oligodendrogenesis.
UNASSIGNED: Four-week-old adolescent mice were subjected to social defeat for 10 days, followed by behavioral tests and evaluations of oligodendroglial proliferation and differentiation.
UNASSIGNED: Stressed mice showed reduced social interaction, more stretched approach posture, lower sucrose preference, but no changes in the forced swimming test. EdU labeled proliferative cells, newly formed NG2+EdU + oligodendrocyte precursor cells (OPCs), and Olig2+EdU+ oligodendrocyte lineage cells (OLLs) were significantly decreased in the mPFC and the lateral habenula, but not in the amygdala and the medial habenula in socially defeated mice. APC+Edu+ newly-generated mature oligodendrocytes (OLs) were decreased in the mPFC in stressed mice. However, the total number of NG2+ OPCs, APC+ mature OLs, and Olig2+ OLLs were comparable in all the brain regions examined between stressed and control mice except for a decrease of APC+ mature OLs in the prelimbic cortex of stressed mice.
UNASSIGNED: Our findings indicate that adolescent social stress causes emotion-related behavioral changes and region-specific impairment of oligodendrogenesis.
摘要：
未经证实：青少年的社会压力会导致与压力相关的情绪障碍。在这项研究中，我们旨在研究三个与压力相关的大脑区域的少突发生，内侧前额叶皮质(mPFC),哈贝努拉,和青春期小鼠的杏仁核暴露于社会失败压力。
未经授权：四周大的青春期老鼠遭受了10天的社交失败，其次是行为测试和少突胶质细胞增殖和分化的评估。
未经授权：压力大的老鼠表现出减少的社会互动，更伸展的接近姿势，较低的蔗糖偏好，但强制游泳测试没有变化.EdU标记的增殖细胞，新形成的NG2+EdU+少突胶质前体细胞（OPCs），和Olig2+EdU+少突胶质细胞谱系细胞（OLL）在mPFC和侧突中显著减少，但不是在社会上失败的老鼠的杏仁核和内侧杂物中。在应激小鼠的mPFC中,APC+Edu+新生成的成熟少突胶质细胞(OL)减少。然而,NG2+OPC的总数，APC+成熟OLs,在应激小鼠和对照小鼠之间检查的所有大脑区域中，Olig2OLL均具有可比性，除了应激小鼠的前边缘皮层中APC成熟OL的减少。
UNASSIGNED：我们的研究结果表明，青少年社会压力会导致情绪相关的行为变化和少突神经发生的区域特异性损害。
未经授权：四周大的青春期老鼠遭受了10天的社交失败，其次是行为测试和少突胶质细胞增殖和分化的评估。
未经授权：压力大的老鼠表现出减少的社会互动，更伸展的接近姿势，较低的蔗糖偏好，但强制游泳测试没有变化.EdU标记的增殖细胞，新形成的NG2+EdU+少突胶质前体细胞（OPCs），和Olig2+EdU+少突胶质细胞谱系细胞（OLL）在mPFC和侧突中显著减少，但不是在社会上失败的老鼠的杏仁核和内侧杂物中。在应激小鼠的mPFC中,APC+Edu+新生成的成熟少突胶质细胞(OL)减少。然而,NG2+OPC的总数，APC+成熟OLs,在应激小鼠和对照小鼠之间检查的所有大脑区域中，Olig2OLL均具有可比性，除了应激小鼠的前边缘皮层中APC成熟OL的减少。
UNASSIGNED：我们的研究结果表明，青少年社会压力会导致情绪相关的行为变化和少突神经发生的区域特异性损害。
