%0 Journal Article
%T Chronic social defeat stress caused region-specific oligodendrogenesis impairment in adolescent mice.
%A Chen H
%A Kang Z
%A Liu X
%A Zhao Y
%A Fang Z
%A Zhang J
%A Zhang H
%J Front Neurosci
%V 16
%N 0
%D 2022
%M 36685249
%F 5.152
%R 10.3389/fnins.2022.1074631
%X <B>UNASSIGNED: </B>Social stress in adolescents precipitates stress-related emotional disorders. In this study we aimed to investigate oligodendrogenesis in three stress-associated brain regions, medial prefrontal cortex (mPFC), habenula, and amygdala in adolescent mice exposed to social defeat stress.<BR><B>UNASSIGNED: </B>Four-week-old adolescent mice were subjected to social defeat for 10 days, followed by behavioral tests and evaluations of oligodendroglial proliferation and differentiation.<BR><B>UNASSIGNED: </B>Stressed mice showed reduced social interaction, more stretched approach posture, lower sucrose preference, but no changes in the forced swimming test. EdU labeled proliferative cells, newly formed NG2+EdU + oligodendrocyte precursor cells (OPCs), and Olig2+EdU+ oligodendrocyte lineage cells (OLLs) were significantly decreased in the mPFC and the lateral habenula, but not in the amygdala and the medial habenula in socially defeated mice. APC+Edu+ newly-generated mature oligodendrocytes (OLs) were decreased in the mPFC in stressed mice. However, the total number of NG2+ OPCs, APC+ mature OLs, and Olig2+ OLLs were comparable in all the brain regions examined between stressed and control mice except for a decrease of APC+ mature OLs in the prelimbic cortex of stressed mice.<BR><B>UNASSIGNED: </B>Our findings indicate that adolescent social stress causes emotion-related behavioral changes and region-specific impairment of oligodendrogenesis.