PDF(Pubmed)
Abstract：
Congenital syphilis is a significant public health problem. Pregnant women infected with Treponema pallidum present with various clinical manifestations, mainly including skin or visceral manifestations. The extensive clinical manifestations of T. pallidum infection mimic those of many other diseases during pregnancy, which may lead to delayed diagnosis and serious consequences. We report a case of fetal T. pallidum infection and premature delivery in a woman whose syphilis screening was negative at 16 weeks of gestation. Despite presenting to the dermatologist at 24 weeks of gestation with maculopapular rash which is usually associated with secondary syphilis, the diagnosis of syphilis was not considered. This case shows that even if early syphilis screening of pregnant women is negative, they may still get infected with T. pallidum later on in pregnancy. Therefore, in patients presenting with a rash without an obvious cause, T. pallidum infection should be excluded. The health status of patients\' spouses should be assessed during pregnancy. Additionally, perinatal health education is necessary for women and their spouses during pregnancy. The abovementioned factors could reduce the probability of T. pallidum infection in pregnant women and their infants.
摘要：
先天性梅毒是一个重要的公共卫生问题。感染梅毒螺旋体的孕妇呈现各种临床表现,主要包括皮肤或内脏表现。梅毒螺旋体感染的广泛临床表现与妊娠期间许多其他疾病相似，这可能导致延迟诊断和严重后果。我们报告了一例胎儿梅毒感染和早产的妇女，其梅毒筛查在妊娠16周时呈阴性。尽管在妊娠24周时出现了通常与二期梅毒相关的斑丘疹，没有考虑梅毒的诊断。此病例表明，即使孕妇的早期梅毒筛查是阴性的，他们在怀孕后可能还会感染梅毒螺旋体.因此,在没有明显原因的皮疹患者中，梅毒螺旋体感染应排除。怀孕期间应评估患者配偶的健康状况。此外,妇女及其配偶在怀孕期间必须进行围产期健康教育。上述因素可降低孕妇及其婴儿梅毒螺旋体感染的概率。
