METHODS: Prospective clinical study.
METHODS: A group of 13 captive adult cheetahs.
METHODS: Cheetahs were immobilised with medetomidine (32-45 μg kg-1) and tiletamine/zolazepam (0.93-1.39 mg kg-1) administered intramuscularly, and anaesthesia was maintained with either isoflurane in oxygen or continuous propofol infusion. Invasive blood pressure was measured via a 20 gauge intra-arterial catheter in the dorsal pedal artery in the metatarsus and used as a reference method for pressures simultaneously estimated using HDO on the contralateral metatarsus and tail base. Bland-Altman plots (for repeated measurements) and criteria defined by the American College of Veterinary Internal Medicine (ACVIM) were used to compare agreement according to the anatomical location of the cuff, the anaesthetic maintenance agent and magnitude of the blood pressure.
RESULTS: A total of 147 paired measurements were obtained with HDO on the metatarsus and 135 on the tail. Agreement with invasive pressures was better when HDO was used on the tail (rather than on the metatarsus) with all ACVIM criteria being met. Mean bias (a positive bias meaning that HDO overestimated the invasively measured pressures) ± standard deviation of differences for systolic, diastolic and mean arterial pressures were -7.0 ± 13.9, 4.2 ±12.1 and 4.6 ±11.2 mmHg, respectively, for HDO on the tail, and -11.9 ±15.1, 2.8 ±16.5 and 2.1 ±13.2 mmHg, respectively, for HDO on the metatarsus. Agreement was better during isoflurane anaesthesia than propofol, and at lower blood pressures than at higher.
CONCLUSIONS: When used on the tail base of anaesthetised cheetahs, HDO met the ACVIM validation criteria for a noninvasive device, as compared to invasively measured pressures in the dorsal pedal artery.
方法:前瞻性临床研究。
方法:一组13只圈养成年猎豹。
方法:肌肉注射美托咪定(32-45μgkg-1)和替他明/唑拉西泮(0.93-1.39mgkg-1)固定猎豹,
结果:使用HDO在meta骨上获得了总共147个配对的测量结果,在尾巴上获得了135个。
结论:当用于麻醉猎豹的尾部时,