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Abstract：
UNASSIGNED: This study aimed to evaluate the global colorectal cancer(CRC) trend and the relevant risk factors from 1990 to 2019 and for better policymaking and resource allocation.
UNASSIGNED: Data on CRC, including incidence, mortality and disability adjusted life year (DALY) rates, were extracted from the 2019 Global Burden of Disease (GBD) study. The estimated annual percentage changes (EAPCs) were calculated to assess the temporal trend of incidence, mortality and DALYs. The Bayesian age-period-cohort model(BAPC) was used to predict the future burden of CRC.
UNASSIGNED: In 2019, a total of 2.17 million CRC cases were reported worldwide, a 157% increase from 1990. In high-social demographic index (SDI) regions, the trend of age-standardized incidence rate(ASIR) tended to decrease, while the proportion of people under 50 years of age tended to increase. Although the number of deaths and DALYs increased, the age-standardized death rate (ASDR) and age-standardized DALY rate decreased. The CRC burden was growing fastest in middle-SDI regions, especially in East Asia, followed by low SDI regions. In addition, the milk intake, High-BMI and high fasting plasma glucose play a more important role in on CRC. The predicted cases and deaths in global continued to increase to 2044. And there is an upward trend in ASIR for both men and women.
UNASSIGNED: In developed regions, the CRC burden continues to decrease, while the CRC burden become more and more severe in developing regions. Overall, the burden of CRC will rising in the near future. Therefore, reasonable resource allocation and prevention policies should be implemented. Developing countries needs more attention.
UNASSIGNED: Data on CRC, including incidence, mortality and disability adjusted life year (DALY) rates, were extracted from the 2019 Global Burden of Disease (GBD) study. The estimated annual percentage changes (EAPCs) were calculated to assess the temporal trend of incidence, mortality and DALYs. The Bayesian age-period-cohort model(BAPC) was used to predict the future burden of CRC.
UNASSIGNED: In 2019, a total of 2.17 million CRC cases were reported worldwide, a 157% increase from 1990. In high-social demographic index (SDI) regions, the trend of age-standardized incidence rate(ASIR) tended to decrease, while the proportion of people under 50 years of age tended to increase. Although the number of deaths and DALYs increased, the age-standardized death rate (ASDR) and age-standardized DALY rate decreased. The CRC burden was growing fastest in middle-SDI regions, especially in East Asia, followed by low SDI regions. In addition, the milk intake, High-BMI and high fasting plasma glucose play a more important role in on CRC. The predicted cases and deaths in global continued to increase to 2044. And there is an upward trend in ASIR for both men and women.
UNASSIGNED: In developed regions, the CRC burden continues to decrease, while the CRC burden become more and more severe in developing regions. Overall, the burden of CRC will rising in the near future. Therefore, reasonable resource allocation and prevention policies should be implemented. Developing countries needs more attention.
摘要：
UNASSIGNED：本研究旨在评估1990年至2019年全球结直肠癌（CRC）趋势和相关风险因素，并更好地制定政策和分配资源。
未经验证：CRC上的数据，包括发病率，死亡率和残疾调整寿命年(DALY)率，摘自2019年全球疾病负担(GBD)研究。计算估计的年度百分比变化（EAPC）以评估发病率的时间趋势，死亡率和DALY。贝叶斯年龄周期队列模型（BAPC）用于预测未来的CRC负担。
UNASSIGNED：2019年，全球共报告了217万例CRC病例，比1990年增加157%。在高社会人口指数(SDI)地区，年龄标准化发病率(ASIR)呈下降趋势，而50岁以下的人口比例有增加的趋势。尽管死亡人数和DALY人数有所增加，年龄标准化死亡率(ASDR)和年龄标准化死亡率下降.在SDI中部地区，CRC负担增长最快，尤其是在东亚，其次是低SDI地区。此外,牛奶摄入量，高BMI和高空腹血糖在CRC发病中的作用越来越重要。到2044年，全球预测的病例和死亡人数继续增加。男性和女性的ASIR都有上升的趋势。
未经评估：在发达地区，儿童权利委员会的负担继续减轻，而发展中地区的CRC负担变得越来越严重。总的来说,在不久的将来，儿童权利委员会的负担将会上升。因此,应实施合理的资源分配和预防政策。发展中国家需要更多的关注。
未经验证：CRC上的数据，包括发病率，死亡率和残疾调整寿命年(DALY)率，摘自2019年全球疾病负担(GBD)研究。计算估计的年度百分比变化（EAPC）以评估发病率的时间趋势，死亡率和DALY。贝叶斯年龄周期队列模型（BAPC）用于预测未来的CRC负担。
UNASSIGNED：2019年，全球共报告了217万例CRC病例，比1990年增加157%。在高社会人口指数(SDI)地区，年龄标准化发病率(ASIR)呈下降趋势，而50岁以下的人口比例有增加的趋势。尽管死亡人数和DALY人数有所增加，年龄标准化死亡率(ASDR)和年龄标准化死亡率下降.在SDI中部地区，CRC负担增长最快，尤其是在东亚，其次是低SDI地区。此外,牛奶摄入量，高BMI和高空腹血糖在CRC发病中的作用越来越重要。到2044年，全球预测的病例和死亡人数继续增加。男性和女性的ASIR都有上升的趋势。
未经评估：在发达地区，儿童权利委员会的负担继续减轻，而发展中地区的CRC负担变得越来越严重。总的来说,在不久的将来，儿童权利委员会的负担将会上升。因此,应实施合理的资源分配和预防政策。发展中国家需要更多的关注。
