Abstract：
BACKGROUND: Globally, type 2 diabetes has become increasing. As little is known about the effect of educational intervention on this population, this systematic review and meta-analysis evaluated the effectiveness of mobile phone text message reminders versus usual care to improve medication adherence among type 2 diabetes mellitus patients.
METHODS: PubMed, Google Scholar, Cochrane Library, Scopus, and African Journals Online, were searched. A random-effects model was employed to estimate combined effect sizes. Subgroup analyses were employed to investigate possible sources of heterogeneity between studies. The overall certainty of the evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation approach.
RESULTS: A total of 9 trials with 1,121 participants were included in the review. The pooled estimated impact of mobile phone text message reminders on medication adherence was (SMD: 0.36; 95%CI; 0.14, 0.59) compared to usual care groups among patients with type 2 diabetes mellitus. In addition, subgroup analyses revealed greater medication adherence levels in those studies with intervention durations of more than six months and with self-report/refill adherence scale measurement (SMD: 0.21; 95%CI: 0.02, 0.40) and (SMD: 0.45; 95%CI: 0.22, 0.68), respectively.
CONCLUSIONS: Mobile phone text messages can potentially lead to improved medication adherence levels in patients with Type 2 diabetes despite heterogeneity across the studies. Therefore, mobile phone text messaging when delivered in addition to usual care, have the potential to produce significant improvements in medication adherence.
METHODS: PubMed, Google Scholar, Cochrane Library, Scopus, and African Journals Online, were searched. A random-effects model was employed to estimate combined effect sizes. Subgroup analyses were employed to investigate possible sources of heterogeneity between studies. The overall certainty of the evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation approach.
RESULTS: A total of 9 trials with 1,121 participants were included in the review. The pooled estimated impact of mobile phone text message reminders on medication adherence was (SMD: 0.36; 95%CI; 0.14, 0.59) compared to usual care groups among patients with type 2 diabetes mellitus. In addition, subgroup analyses revealed greater medication adherence levels in those studies with intervention durations of more than six months and with self-report/refill adherence scale measurement (SMD: 0.21; 95%CI: 0.02, 0.40) and (SMD: 0.45; 95%CI: 0.22, 0.68), respectively.
CONCLUSIONS: Mobile phone text messages can potentially lead to improved medication adherence levels in patients with Type 2 diabetes despite heterogeneity across the studies. Therefore, mobile phone text messaging when delivered in addition to usual care, have the potential to produce significant improvements in medication adherence.
摘要：
背景：在全球范围内，2型糖尿病越来越多。由于对教育干预对这一人群的影响知之甚少，本系统综述和荟萃分析评估了手机短信提醒与常规护理相比,在2型糖尿病患者中提高用药依从性的有效性.
方法：PubMed，谷歌学者，科克伦图书馆,Scopus,和非洲在线期刊，被搜查了。采用随机效应模型来估计组合效应大小。亚组分析用于调查研究之间异质性的可能来源。使用建议分级评估对证据的总体确定性进行评估，发展,和评价方法。
结果：共有9项试验纳入了1,121名参与者。在2型糖尿病患者中，与常规护理组相比，手机短信提醒对药物依从性的综合估计影响为（SMD：0.36；95CI；0.14，0.59）。此外,亚组分析显示，在干预持续时间超过6个月和自我报告/补充依从性量表测量的研究中，药物依从性水平更高(SMD:0.21;95CI:0.02,0.40)和(SMD:0.45;95CI:0.22,0.68)，分别。
结论：手机短信有可能改善2型糖尿病患者的用药依从性，尽管这些研究存在异质性。因此,除了通常的护理外，手机短信在交付时，有可能显著改善药物依从性。
方法：PubMed，谷歌学者，科克伦图书馆,Scopus,和非洲在线期刊，被搜查了。采用随机效应模型来估计组合效应大小。亚组分析用于调查研究之间异质性的可能来源。使用建议分级评估对证据的总体确定性进行评估，发展,和评价方法。
结果：共有9项试验纳入了1,121名参与者。在2型糖尿病患者中，与常规护理组相比，手机短信提醒对药物依从性的综合估计影响为（SMD：0.36；95CI；0.14，0.59）。此外,亚组分析显示，在干预持续时间超过6个月和自我报告/补充依从性量表测量的研究中，药物依从性水平更高(SMD:0.21;95CI:0.02,0.40)和(SMD:0.45;95CI:0.22,0.68)，分别。
结论：手机短信有可能改善2型糖尿病患者的用药依从性，尽管这些研究存在异质性。因此,除了通常的护理外，手机短信在交付时，有可能显著改善药物依从性。
