This study aimed to evaluate the effect of exercise on intrahepatic lipid (IHL), serum alanine aminotransferase (ALT), body mass index (BMI), and insulin resistance in NAFLD patients.
We searched MEDLINE, Embase, Cochrane CENTRAL, KMbase, and the Korean Studies Information Service System through April 2022. The included studies were randomised control trials (RCTs) of exercise, in which IHL was measured using magnetic resonance imaging in adult NAFLD patients.
Eleven RCTs with 577 participants were included in this meta-analysis. Exercise was significantly associated with a reduction in IHL (mean difference (MD), -2.03; 95% CI, -3.26 to -0.79; P = 0.001) and a decrease in ALT (MD, -4.17; 95% CI, -6.60 to -1.73; P = 0.0008). Regarding the duration of exercise, maintaining exercise for more than 3 months significantly improved IHL (MD, -3.62; 95% CI, -5.76 to -1.48; P = 0.0009), while exercise for less than 3 months did not (MD, -1.23; 95% CI, -2.74 to 0.29; P = 0.11). BMI and insulin resistance did not improve significantly with exercise.
We found that exercise improved IHL and ALT levels in NAFLD patients. The effect of exercise is particularly increased when one engages in exercises that last longer than 3 months.
目的:本研究旨在评估运动对肝内脂质(IHL)的影响,血清丙氨酸转氨酶(ALT),体重指数(BMI),NAFLD患者的胰岛素抵抗。
方法:我们搜索了MEDLINE,Embase,科克伦中部,KMbase,和韩国研究信息服务系统到2022年4月。纳入的研究是运动的随机对照试验(RCTs),在成人NAFLD患者中使用磁共振成像测量IHL。
结果:本荟萃分析纳入了11项RCT,577名参与者。运动与IHL的减少显著相关(平均差(MD),-2.03;95%CI,-3.26至-0.79;P=0.001)和ALT降低(MD,-4.17;95%CI,-6.60至-1.73;P=0.0008)。关于锻炼的持续时间,保持运动超过3个月显著改善了IHL(MD,-3.62;95%CI,-5.76至-1.48;P=0.0009),而运动少于3个月没有(MD,-1.23;95%CI,-2.74至0.29;P=0.11)。运动后BMI和胰岛素抵抗没有明显改善。
结论:我们发现运动可改善NAFLD患者的IHL和ALT水平。当一个人进行持续超过3个月的锻炼时,锻炼的效果会特别增加。