Abstract：
The clinical success of a drug delivery system turns back to performing experiments with more reliable data. The dialysis bag has been one of the most employed technologies to monitor drug release from nanocarriers, membranes, and scaffolds. Unfortunately, this technology has several challenges regarding the accuracy of the obtained results. In this study, the development of a new system by integrating a microfluidic device and dialysis bag named \"MF-dialysis\" was carried out to evaluate the accuracy of the reported data. The release study was performed focusing on two drug delivery systems: (i) nanocarrier: Artemisia Absinthium extract-loaded soy protein isolate nanoparticle and (ii) sodium alginate film loaded with the nanocarrier. The obtained nanocarrier was analyzed by SEM, DLS, and zeta potential. The final experimental data were modeled using SigmaPlot software. Based on the results, two distinct but fitted models for the dialysis bag (power model, R2 = 0.99) and MF-dialysis (exponential model, R2 = 0.95) were obtained. MF-dialysis approved that after a while, NPs and films showed more drug release compared to the dialysis bag. To sum up, the MF-dialysis system can be a good candidate for a quick and more reliable study of drug delivery systems.
摘要：
药物递送系统的临床成功回到具有更可靠数据的实验。透析袋一直是监测纳米载体药物释放的最常用技术之一，膜，和脚手架。不幸的是,这项技术在获得结果的准确性方面有几个挑战。在这项研究中,通过集成微流体装置和名为“MF-透析”的透析袋开发了一种新系统，以评估报告数据的准确性。集中于两种药物递送系统进行释放研究:(i)纳米载体:装载苦艾提取物的大豆分离蛋白纳米颗粒和(ii)装载有纳米载体的藻酸钠膜。通过SEM分析获得的纳米载体,DLS,和zeta电位。使用SigmaPlot软件对最终实验数据进行建模。根据结果,透析袋的两个不同但合适的模型(动力模型，R2=0.99)和MF透析(指数模型，获得R2=0.95)。MF透析批准了一段时间后，与透析袋相比,NP和薄膜显示出更多的药物释放。总而言之,MF透析系统可以是快速和更可靠的药物输送系统研究的良好候选者。
