Abstract：
Herb medicine has a long history of application and is still used worldwide. With the development of complementary and alternative medicine, the interaction between herb and drugs has attracted more and more attention. Herb-drug interactions (HDI) could cause decreased efficiency, increased toxicity, and affect the drug absorption and disposition processes due to the interference of their pharmacological or pharmacokinetic effects. Hence, the mechanisms and results of herb-pharmacokinetic interactions should be comprehensively summarized. Here, we have summarized the mechanisms of HDI and pharmacokinetic interactions in the last ten years based on searching on PubMed, Science Direct, and Web of Science with different keywords. Besides, the pharmacokinetic interactions were related to nine commonly used herbs and drugs, including Ginseng, Salvia miltiorrhiza, Ginkgo biloba, Garlic, Coptis chinensis, St. John\'s wort, Ginger, Licorice, Silythistle and Fructus Schisandrae. This review provides an overview of HDI to provide a reference for the rational and safe clinical use of herbs and drugs.
摘要：
草药具有悠久的应用历史，并且仍然在世界范围内使用。随着补充医学和替代医学的发展,中草药与药物之间的相互作用越来越受到重视。草药-药物相互作用（HDI）可能导致效率下降，毒性增加，并由于其药理或药代动力学作用的干扰而影响药物的吸收和处置过程。因此，应全面总结草药-药代动力学相互作用的机制和结果。这里,我们在PubMed搜索的基础上总结了最近十年的HDI和药代动力学相互作用的机制，科学直接，和WebofScience具有不同的关键字。此外,药代动力学相互作用与九种常用草药和药物有关，包括人参,丹参,银杏,大蒜,黄连,圣约翰麦汁，生姜,丽可丽斯,水飞蓟及五味子.本文对HDI进行综述,为临床合理、安全使用中草药和药物提供参考。
