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Abstract：
This systematic review and meta-analysis aimed to compare the effects of high-intensity interval exercise (HIIE) with different recovery modes versus moderate-intensity continuous exercise (MICE) on cardiac troponin (cTn) elevation.
A literature search was conducted in four databases: Scopus, PubMed, EBSCO and Web of Science from January 2010 to June 2022. The articles were screened, evaluated for quality before data were extracted. The review protocol was registered at PROSPERO (CRD42021245649). Standardized mean differences (SMD) of peak cTn were analyzed with a 95% confidence interval (95% CI) using Revman 5.4 software.
Six studies satisfied the inclusion criteria with a total of 92 and 79 participants for HIIE and MICE, respectively. Overall, there was no significant difference between HIIE and MICE in the elevation of cardiac troponin T (SMD: 0.41 [95% CI [-0.21, 1.03]], p = 0.20, I 2 = 77%, p for heterogeneity <0.01). In subgroup analysis, HIIE with passive recovery elicits greater release of cardiac troponin T than MICE (SMD: 0.85 [95% CI [0.44, 1.27]], p < 0.01, I 2 = 32%, p for heterogeneity = 0.22). Changes of cardiac troponin T (SMD: 0.41 [95% CI [-0.21, 1.03]], p = 0.20, I 2 = 77%, p for heterogeneity < 0.01) after HIIE with active recovery were not significantly different from those of MICE.
There was no significant difference between HIIE and MICE in the elevation of cardiac troponin T. However, HIIE with passive recovery elicited more cardiac troponin T elevation than MICE, which should be considered when developing exercise programs.
A literature search was conducted in four databases: Scopus, PubMed, EBSCO and Web of Science from January 2010 to June 2022. The articles were screened, evaluated for quality before data were extracted. The review protocol was registered at PROSPERO (CRD42021245649). Standardized mean differences (SMD) of peak cTn were analyzed with a 95% confidence interval (95% CI) using Revman 5.4 software.
Six studies satisfied the inclusion criteria with a total of 92 and 79 participants for HIIE and MICE, respectively. Overall, there was no significant difference between HIIE and MICE in the elevation of cardiac troponin T (SMD: 0.41 [95% CI [-0.21, 1.03]], p = 0.20, I 2 = 77%, p for heterogeneity <0.01). In subgroup analysis, HIIE with passive recovery elicits greater release of cardiac troponin T than MICE (SMD: 0.85 [95% CI [0.44, 1.27]], p < 0.01, I 2 = 32%, p for heterogeneity = 0.22). Changes of cardiac troponin T (SMD: 0.41 [95% CI [-0.21, 1.03]], p = 0.20, I 2 = 77%, p for heterogeneity < 0.01) after HIIE with active recovery were not significantly different from those of MICE.
There was no significant difference between HIIE and MICE in the elevation of cardiac troponin T. However, HIIE with passive recovery elicited more cardiac troponin T elevation than MICE, which should be considered when developing exercise programs.
摘要：
UNASSIGNED：本系统综述和荟萃分析旨在比较不同恢复模式下的高强度间歇运动（HIIE）与中等强度连续运动（MICE）对心肌肌钙蛋白（cTn）升高的影响。
UNASSIGNED：在四个数据库中进行了文献检索：Scopus，PubMed,2010年1月至2022年6月，EBSCO和WebofScience。文章经过筛选，在提取数据之前对质量进行评估。审查方案在PROSPERO(CRD42021245649)注册。使用Revman5.4软件以95%置信区间(95%CI)分析峰值cTn的标准化平均差异(SMD)。
UNASSIGNED：六项研究符合纳入标准，共有92名和79名参与者参加了HIIE和MICE，分别。总的来说,TherewasnosignificantdifferencebetweenHIIEandMICEintheelevationofcardistictomponinT(SMD:0.41[95%CI[-0.21,1.03]],p=0.20，I2=77%，P表示异质性<0.01)。在亚组分析中，HIIEwithpassiverecoveryelicationsgreaterreleaseofcardistheartonthanMICE(SMD:0.85[95%CI[0.44,1.27]],p<0.01，I2=32%，异质性的p=0.22)。心脏肌钙蛋白T的变化（SMD：0.41[95%CI[-0.21,1.03]]，p=0.20，I2=77%，P为异质性<0.01），经HIIE主动恢复后与MICE无显着差异。
未经证实：HIIE和MICE在心肌肌钙蛋白T升高方面没有显著差异。被动恢复的HIIE比MICE引起更多的心肌肌钙蛋白T升高，在制定锻炼计划时应该考虑这一点。
UNASSIGNED：在四个数据库中进行了文献检索：Scopus，PubMed,2010年1月至2022年6月，EBSCO和WebofScience。文章经过筛选，在提取数据之前对质量进行评估。审查方案在PROSPERO(CRD42021245649)注册。使用Revman5.4软件以95%置信区间(95%CI)分析峰值cTn的标准化平均差异(SMD)。
UNASSIGNED：六项研究符合纳入标准，共有92名和79名参与者参加了HIIE和MICE，分别。总的来说,TherewasnosignificantdifferencebetweenHIIEandMICEintheelevationofcardistictomponinT(SMD:0.41[95%CI[-0.21,1.03]],p=0.20，I2=77%，P表示异质性<0.01)。在亚组分析中，HIIEwithpassiverecoveryelicationsgreaterreleaseofcardistheartonthanMICE(SMD:0.85[95%CI[0.44,1.27]],p<0.01，I2=32%，异质性的p=0.22)。心脏肌钙蛋白T的变化（SMD：0.41[95%CI[-0.21,1.03]]，p=0.20，I2=77%，P为异质性<0.01），经HIIE主动恢复后与MICE无显着差异。
未经证实：HIIE和MICE在心肌肌钙蛋白T升高方面没有显著差异。被动恢复的HIIE比MICE引起更多的心肌肌钙蛋白T升高，在制定锻炼计划时应该考虑这一点。
