Abstract：
Analysis of hair samples provides unique advantages, including non-invasive sampling, sample stability, and the possibility of additional optimization of high sensitivity detection methods. Hair sample analysis is often used in psychiatric disease research to evaluate previous periods of stress encountered by patients. Glucocorticoid analysis is the most frequently tested indicator of stress. Furthermore, the hypothalamus-pituitary-gonad axis and endocannabinoid system also are involved in the occurrence and development of mental disorders. The endocannabinoid and sex hormone levels in patients experiencing mental illness are considerably different from levels observed in healthy individuals. Nevertheless, due to the different methods used to assess the degree of disease and the range of analytical methods involved in clinical research, the trends in changes for these biomarkers are not uniform. The correlations between changes in biomarker concentrations and illness severity also are not clear. The observed alterations suggest these biochemical substances in hair have potential as biomarkers for diagnosis or predictive treatment. However, the variable results obtained thus far could hamper further development of hair samples for clinical assessment in psychiatric disorders. This article summarizes the published reports documenting the changes in the content of relevant substances in hair in individuals experiencing mental illness and the degree of correlation. In the discussion section, we proposed several issues that should be considered in future studies of hair samples obtained from patients with mental disorders to promote the use of hair sample assessment as an aid in diagnosis or predictive treatment.
摘要：
头发样品的分析提供了独特的优势，包括非侵入性采样，样品稳定性，以及高灵敏度检测方法的额外优化的可能性。头发样本分析通常用于精神疾病研究，以评估患者先前遇到的压力时期。糖皮质激素分析是最常测试的应激指标。此外，下丘脑-垂体-性腺轴和内源性大麻素系统也参与了精神障碍的发生和发展。患有精神疾病的患者的内源性大麻素和性激素水平与健康个体中观察到的水平有很大不同。然而，由于用于评估疾病程度的方法不同以及临床研究中涉及的分析方法的范围不同，这些生物标志物的变化趋势并不一致.生物标志物浓度的变化与疾病严重程度之间的相关性也不清楚。观察到的变化表明头发中的这些生化物质具有作为诊断或预测性治疗的生物标志物的潜力。然而,迄今为止获得的可变结果可能会阻碍进一步开发用于精神疾病临床评估的头发样本.本文总结了已发表的报告，这些报告记录了患有精神疾病的人头发中相关物质的含量变化以及相关程度。在讨论部分,我们提出了在未来对精神疾病患者的头发样本进行研究时应考虑的几个问题,以促进头发样本评估作为诊断或预测性治疗的辅助手段.
