Abstract：
Many clinical trials have revealed that flaxseed supplementation might exert a potent antihypertensive influence, but the findings are inconsistent. In this regard, a meta-analysis was carried out to provide a more accurate estimate of the impact of flaxseed supplementation on blood pressure. We searched international databases including PubMed, Cochrane Library, Web of Science, Scopus, Embase, and Google Scholar till July 2022. A random-effects model was used to calculate weighted mean differences (WMDs). Non-linear dose-response analysis and meta-regression were performed. Meta-analysis of 33 trials (comprising 43 treatment arms) with 2427 participants revealed significant reductions in both systolic (WMD: -3.19 mmHg; 95% CI: -4.15 to -2.24, p < 0.001; I2 = 92.5%, p < 0.001) and diastolic blood pressure (WMD = -2.61 mmHg; 95% CI: -3.27, -1.94, p < 0.001; I2 = 94.1%, p < 0.001) following flaxseed supplementation. Greater effects on SBP and DBP were found in trials with an intervention duration of >20 weeks, ≥30 g day-1 of flaxseed, subjects with BMI 25-30 kg m-2, and in patients with hypertension. Supplementation with various flaxseed products significantly reduced SBP and DBP levels, confirming the hypothesis that flaxseed could be used as an effective supplement for blood pressure management, alongside routine medications.
摘要：
许多临床试验表明，亚麻籽补充剂可能发挥有效的抗高血压作用，但是调查结果不一致。在这方面,我们进行了一项荟萃分析,以更准确地评估补充亚麻籽对血压的影响.我们搜索了包括PubMed在内的国际数据库，科克伦图书馆,WebofScience,Scopus,Embase,和谷歌学者直到2022年7月。随机效应模型用于计算加权平均差(WMD)。进行非线性剂量反应分析和荟萃回归。对33项试验（包括43个治疗组）对2427名参与者进行的荟萃分析显示，收缩压均显着降低（WMD：-3.19mmHg；95％CI：-4.15至-2.24，p<0.001；I2=92.5％，p<0.001）和舒张压（WMD=-2.61mmHg；95％CI：-3.27，-1.94，p<0.001；I2=94.1％，补充亚麻籽后p<0.001)。在干预持续时间>20周的试验中发现对SBP和DBP的影响更大，≥30g第1天的亚麻籽，BMI为25-30kgm-2的受试者，以及高血压患者。补充各种亚麻籽产品显着降低SBP和DBP水平，证实了亚麻籽可以用作血压管理的有效补充剂的假设，除了常规药物。
