PDF(Pubmed)
Abstract：
UNASSIGNED: Induction of anesthesia for emergency procedures, without prior gastric preparation and incomplete fasting, is associated with the risk of reflux of stomach contents and aspiration. This study aimed to evaluate the effect of intravenous (IV) metoclopramide administration on gastric emptying in opium users, candidate for procedural sedation and analgesia (PSA).
UNASSIGNED: In the present case-control study, opium-dependent (case) and non-dependent (control) patients in need of PSA were administered with 10 mg IV metoclopramide after undergoing gastric ultrasonography for determination of its area and contents. Then, 30 minutes after the administration of metoclopramide, the area and contents of the stomach were measured again and compared with the measures obtained before the intervention.
UNASSIGNED: 135 patients were evaluated in three groups of 45, including the case, control, and placebo groups. The three groups were similar regarding mean age (p = 0.068), sex (p = 0.067), weight (p = 0.596), height (p = 0.671), body mass index (BMI) (p = 0.877), duration of fasting (p = 0.596), and type of gastric contents (p = 0.124). Mean antral cross-sectional area (CSA) of the study participants in the case, control, and placebo groups before the administration of the drug was 8.49 ± 1.40, 8.31 ± 2.56, and 6.56 ± 1.72 cm2, respectively. Mean gastric area in the case (p < 0.001) and control (p < 0.001) groups had significantly decreased after the intervention. Mean antral gastric grade of gastric contents in the case (p < 0.001) and control (p < 0.001) groups had significantly decreased after the intervention.
UNASSIGNED: It seems that metoclopramide administration in opium users in need of PSA leads to a significant decrease in mean gastric area and increases gastric emptying.
UNASSIGNED: In the present case-control study, opium-dependent (case) and non-dependent (control) patients in need of PSA were administered with 10 mg IV metoclopramide after undergoing gastric ultrasonography for determination of its area and contents. Then, 30 minutes after the administration of metoclopramide, the area and contents of the stomach were measured again and compared with the measures obtained before the intervention.
UNASSIGNED: 135 patients were evaluated in three groups of 45, including the case, control, and placebo groups. The three groups were similar regarding mean age (p = 0.068), sex (p = 0.067), weight (p = 0.596), height (p = 0.671), body mass index (BMI) (p = 0.877), duration of fasting (p = 0.596), and type of gastric contents (p = 0.124). Mean antral cross-sectional area (CSA) of the study participants in the case, control, and placebo groups before the administration of the drug was 8.49 ± 1.40, 8.31 ± 2.56, and 6.56 ± 1.72 cm2, respectively. Mean gastric area in the case (p < 0.001) and control (p < 0.001) groups had significantly decreased after the intervention. Mean antral gastric grade of gastric contents in the case (p < 0.001) and control (p < 0.001) groups had significantly decreased after the intervention.
UNASSIGNED: It seems that metoclopramide administration in opium users in need of PSA leads to a significant decrease in mean gastric area and increases gastric emptying.
摘要：
未经授权：紧急手术麻醉诱导，没有事先的胃准备和不完全的禁食，与胃内容物反流和误吸的风险有关。本研究旨在评估静脉注射（IV）甲氧氯普胺对鸦片使用者胃排空的影响，程序镇静和镇痛（PSA）的候选人。
未经评估：在本病例对照研究中，需要PSA的鸦片依赖性（病例）和非依赖性（对照）患者在接受胃超声检查以确定其面积和含量后，分别给予10mgIV甲氧氯普胺。然后，服用甲氧氯普胺30分钟后，再次测量胃的面积和内容物，并与干预前获得的测量结果进行比较。
UNASSIGNED：对135例患者进行了评估，每组45例，包括病例，control,和安慰剂组。三组的平均年龄相似（p=0.068），性别（p=0.067），体重（p=0.596），高度（p=0.671），体重指数（BMI）（p=0.877），禁食持续时间（p=0.596），和胃内容物类型（p=0.124）。病例中研究参与者的平均窦横截面积(CSA)，control,给药前安慰剂组分别为8.49±1.40、8.31±2.56和6.56±1.72cm2。干预后，病例组（p<0.001）和对照组（p<0.001）的平均胃面积显着降低。干预后，病例组（p<0.001）和对照组（p<0.001）的胃内容物的平均胃窦分级显着降低。
UNASSIGNED：似乎需要PSA的鸦片使用者服用甲氧氯普胺会导致平均胃面积显着减少并增加胃排空。
未经评估：在本病例对照研究中，需要PSA的鸦片依赖性（病例）和非依赖性（对照）患者在接受胃超声检查以确定其面积和含量后，分别给予10mgIV甲氧氯普胺。然后，服用甲氧氯普胺30分钟后，再次测量胃的面积和内容物，并与干预前获得的测量结果进行比较。
UNASSIGNED：对135例患者进行了评估，每组45例，包括病例，control,和安慰剂组。三组的平均年龄相似（p=0.068），性别（p=0.067），体重（p=0.596），高度（p=0.671），体重指数（BMI）（p=0.877），禁食持续时间（p=0.596），和胃内容物类型（p=0.124）。病例中研究参与者的平均窦横截面积(CSA)，control,给药前安慰剂组分别为8.49±1.40、8.31±2.56和6.56±1.72cm2。干预后，病例组（p<0.001）和对照组（p<0.001）的平均胃面积显着降低。干预后，病例组（p<0.001）和对照组（p<0.001）的胃内容物的平均胃窦分级显着降低。
UNASSIGNED：似乎需要PSA的鸦片使用者服用甲氧氯普胺会导致平均胃面积显着减少并增加胃排空。
