UNASSIGNED: We searched Medline and Scopus databases for English-language articles from inception through October 2021. Data were extracted from the included publications by two independent reviewers. We performed bivariate meta-analysis with a random-effects model to pool diagnostic parameters. Meta-regression and subgroup analyses were performed to explore heterogeneity sources. We used network meta-analysis to compare diagnosis performance among the three criteria and ranked them in descending order. Publication bias was assessed using Deeks\' funnel plot.
UNASSIGNED: We included 29 studies for systematic review and meta-analysis. Of these, 18 studies involved adult-onset SLE and 11 studies involved childhood-onset SLE. The pooled sensitivities of the three criteria for diagnosis of adult-onset SLE were comparable between SLICC 2012 and EULAR/ACR 2019 [95.86, 95% confidence interval (CI) 92.28-97.81 vs. 94.79, 95% CI 92.03-96.63]; pooled specificity was highest in ACR 1997 (92.24, 95% CI 87.06-95.46). In childhood-onset SLE, pooled sensitivity was highest in SLICC 2012 (93.76, 95% CI 89.45-96.39), and pooled specificity was highest in ACR 1997 (95.89, 95% CI 91.73-98.00). In network meta-analysis, the pooled diagnostic odds ratio ranked highest for EULAR/ACR 2019 (131.570, 95% CI 61.50-281.47) in adult-onset SLE and ranked highest for SLICC 2012 (191.07, 95% CI 76.06-480.01) in childhood-onset SLE. Deeks\' funnel plot showed no publication bias.
UNASSIGNED: We found that the diagnostic performance of the ACR 1997, SLICC 2012, and EULAR/ACR 2019 criteria differed between adult-onset and childhood-onset SLE. EULAR/ACR 2019 performed best for adult-onset SLE and SLICC 2012 was best for childhood-onset SLE in classifying patients with SLE.
UNASSIGNED: [www.ClinicalTrials.gov], identifier [CRD420 21281586].
UNASSIGNED:我们在Medline和Scopus数据库中搜索了从成立到2021年10月的英文文章。数据由两名独立审稿人从所包括的出版物中提取。我们使用随机效应模型进行了双变量荟萃分析,以汇集诊断参数。进行Meta回归和亚组分析以探索异质性来源。我们使用网络荟萃分析来比较三个标准之间的诊断性能,并按降序排列它们。使用Deeks漏斗图评估发表偏倚。
UASSIGNED:我们纳入了29项研究进行系统评价和荟萃分析。其中,18项研究涉及成人发作性SLE,11项研究涉及儿童发作性SLE。SLICC2012和EULAR/ACR2019之间诊断成人发作性SLE的三种标准的合并敏感性相当[95.86,95%置信区间(CI)92.28-97.81vs.94.79,95%CI92.03-96.63];合并特异性在ACR1997中最高(92.24,95%CI87.06-95.46)。在儿童发作的SLE中,2012年SLICC的合并敏感性最高(93.76,95%CI89.45-96.39),在ACR1997中,合并特异性最高(95.89,95%CI91.73-98.00)。在网络荟萃分析中,在成人发作性SLE中,EULAR/ACR2019的汇总诊断比值比最高(131.570,95%CI61.50-281.47),在儿童发作性SLE中,SLICC2012的汇总诊断比值比最高(191.07,95%CI76.06-480.01).Deeks漏斗图没有发表偏倚。
未经评估:我们发现ACR1997、SLICC2012和EULAR/ACR2019标准的诊断性能在成人发作和儿童发作SLE之间存在差异。在SLE患者分类方面,EULAR/ACR2019对成人发作的SLE表现最佳,SLICC2012对儿童发作的SLE表现最佳。
未经批准:[www.ClinicalTrials.gov],标识符[CRD42021281586]。