PDF(Pubmed)
Abstract：
UNASSIGNED: Sodium Fluorescein has become a validated and widely used fluorescent dye in neuro-oncological surgery, thanks to its ability to accumulate in cerebral with a damaged blood-brain barrier. It concentrates at the tumor site, enhancing the lesion, and helps in the discrimination between tumor and normal brain parenchyma.
UNASSIGNED: This dye has a very well described profile of safeness, as a result of several applications in ophthalmology and, in recent years, also in neurosurgery. To date, no reviews are available on collateral effects of sodium fluorescein application in neurosurgery.
UNASSIGNED: The case of a young woman who underwent a potentially toxic dose (almost 3 g) of sodium fluroescein administration during anesthesia induction for a glioma surgery due to a medical error is presented, along with a review of available articles relates to collateral effects of sodium fluorescein in neurosurgery.
UNASSIGNED: No toxic clinical phenomena occurred, and the microsurgical procedure was completed, achieving tumor gross total resection. Procedure resulted challenging due to an intense basal hyper-fluorescence, making difficult the visualization of brain tissues and the discrimination between normal brain and tumor.
UNASSIGNED: The good clinical and laboratory outcome of this patient further strengthens the idea that fluorescein-guided removal of brain tumors may be considered safe, beyond effective. By now, this is the first report of an erroneous so high dose administration of sodium fluorescein during a neurosurgical procedure and the first review of neurosurgical-reported collateral effects.
UNASSIGNED: This dye has a very well described profile of safeness, as a result of several applications in ophthalmology and, in recent years, also in neurosurgery. To date, no reviews are available on collateral effects of sodium fluorescein application in neurosurgery.
UNASSIGNED: The case of a young woman who underwent a potentially toxic dose (almost 3 g) of sodium fluroescein administration during anesthesia induction for a glioma surgery due to a medical error is presented, along with a review of available articles relates to collateral effects of sodium fluorescein in neurosurgery.
UNASSIGNED: No toxic clinical phenomena occurred, and the microsurgical procedure was completed, achieving tumor gross total resection. Procedure resulted challenging due to an intense basal hyper-fluorescence, making difficult the visualization of brain tissues and the discrimination between normal brain and tumor.
UNASSIGNED: The good clinical and laboratory outcome of this patient further strengthens the idea that fluorescein-guided removal of brain tumors may be considered safe, beyond effective. By now, this is the first report of an erroneous so high dose administration of sodium fluorescein during a neurosurgical procedure and the first review of neurosurgical-reported collateral effects.
摘要：
未经证实：荧光素钠已成为神经肿瘤外科中一种经过验证和广泛使用的荧光染料，由于其在大脑中积累的能力与受损的血脑屏障。它集中在肿瘤部位，增强病变，并有助于区分肿瘤和正常脑实质。
未经评估：这种染料具有非常好的安全性描述，由于在眼科和，近年来,也在神经外科。迄今为止,目前尚无关于荧光素钠在神经外科应用的附带影响的评论。
UNASSIGNED：介绍了一名年轻女性由于医疗错误在神经胶质瘤手术麻醉诱导期间接受潜在毒性剂量（近3克）的氟西沙钠给药的情况。以及对现有文章的评论，涉及荧光素钠在神经外科中的附带作用。
未经批准：没有出现毒性临床现象，显微外科手术完成了，实现肿瘤全切除。由于强烈的基底超荧光，程序具有挑战性，使脑组织的可视化以及正常大脑和肿瘤之间的区分变得困难。
UNASSIGNED：该患者良好的临床和实验室结果进一步加强了荧光素引导的脑肿瘤切除可能被认为是安全的观点，超越有效。到现在为止,这是首次报道神经外科手术期间如此高剂量的荧光素钠给药错误,也是首次回顾神经外科报道的附带影响.
未经评估：这种染料具有非常好的安全性描述，由于在眼科和，近年来,也在神经外科。迄今为止,目前尚无关于荧光素钠在神经外科应用的附带影响的评论。
UNASSIGNED：介绍了一名年轻女性由于医疗错误在神经胶质瘤手术麻醉诱导期间接受潜在毒性剂量（近3克）的氟西沙钠给药的情况。以及对现有文章的评论，涉及荧光素钠在神经外科中的附带作用。
未经批准：没有出现毒性临床现象，显微外科手术完成了，实现肿瘤全切除。由于强烈的基底超荧光，程序具有挑战性，使脑组织的可视化以及正常大脑和肿瘤之间的区分变得困难。
UNASSIGNED：该患者良好的临床和实验室结果进一步加强了荧光素引导的脑肿瘤切除可能被认为是安全的观点，超越有效。到现在为止,这是首次报道神经外科手术期间如此高剂量的荧光素钠给药错误,也是首次回顾神经外科报道的附带影响.
