Abstract：
BACKGROUND: Anti-IgLON5 disease is a rare chronic autoimmune-mediated tauopathy, featured by the sleep disturbance. Several studies have described its clinical characteristics, however, the simultaneous occurrence of anti-IgLON5 disease and rectal cancer has not been reported. We described an unusual entity of anti-IgLON5 disease complicated with rectal cancer.
METHODS: A 76-year-old man initially presented with slurred speech and limb tremors, followed by epileptic-like seizures, lethargy, and sleep apnea. IgG anti-IgLON5 antibodies were positive in both serum and cerebrospinal fluid. The patient responded well to the treatment of plasma exchange and a pulse and gradual reduction of steroids therapy. When the oral steroids started, mycophenolate mofetil was added. Two months later, the patient had bloody stools and pathological-confirmed moderately differentiated adenocarcinoma of the rectum.
CONCLUSIONS: Whereas sleep disturbance is the most common feature in patients with anti-IgLON5 disease, our case presented with slurred speech and limb tremors. Anti-IgLON5 disease complicated with rectal cancer is very rare. Tumor screening should be considered in patients with anti-IgLON5 disease to investigate the association between tumor and this disease.
METHODS: A 76-year-old man initially presented with slurred speech and limb tremors, followed by epileptic-like seizures, lethargy, and sleep apnea. IgG anti-IgLON5 antibodies were positive in both serum and cerebrospinal fluid. The patient responded well to the treatment of plasma exchange and a pulse and gradual reduction of steroids therapy. When the oral steroids started, mycophenolate mofetil was added. Two months later, the patient had bloody stools and pathological-confirmed moderately differentiated adenocarcinoma of the rectum.
CONCLUSIONS: Whereas sleep disturbance is the most common feature in patients with anti-IgLON5 disease, our case presented with slurred speech and limb tremors. Anti-IgLON5 disease complicated with rectal cancer is very rare. Tumor screening should be considered in patients with anti-IgLON5 disease to investigate the association between tumor and this disease.
摘要：
背景：抗IgLON5病是一种罕见的慢性自身免疫介导的tau蛋白病，以睡眠障碍为特征。一些研究已经描述了其临床特征，然而,尚未报道同时发生抗IgLON5疾病和直肠癌。我们描述了一种不寻常的抗IgLON5疾病并发直肠癌的实体。
方法：一名76岁的男子最初表现为言语不清和肢体震颤，接着是癫痫样发作,嗜睡,和睡眠呼吸暂停。IgG抗IgLON5抗体在血清和脑脊液中均呈阳性。患者对血浆置换治疗和类固醇治疗的脉冲和逐渐减少反应良好。当口服类固醇开始时，加入霉酚酸酯。两个月后,患者出现血便和病理证实的直肠中分化腺癌.
结论：尽管睡眠障碍是抗IgLON5病患者最常见的特征，我们的病例表现为言语不清和肢体震颤。抗IgLON5病并发直肠癌非常罕见。在患有抗IgLON5疾病的患者中，应考虑进行肿瘤筛查，以研究肿瘤与该疾病之间的关系。
方法：一名76岁的男子最初表现为言语不清和肢体震颤，接着是癫痫样发作,嗜睡,和睡眠呼吸暂停。IgG抗IgLON5抗体在血清和脑脊液中均呈阳性。患者对血浆置换治疗和类固醇治疗的脉冲和逐渐减少反应良好。当口服类固醇开始时，加入霉酚酸酯。两个月后,患者出现血便和病理证实的直肠中分化腺癌.
结论：尽管睡眠障碍是抗IgLON5病患者最常见的特征，我们的病例表现为言语不清和肢体震颤。抗IgLON5病并发直肠癌非常罕见。在患有抗IgLON5疾病的患者中，应考虑进行肿瘤筛查，以研究肿瘤与该疾病之间的关系。
