PDF(Pubmed)
Abstract：
Empathy relies on fronto-cingular and temporal networks that are selectively vulnerable in behavioral variant frontotemporal dementia (bvFTD). This study modeled when in the disease process empathy changes begin, and how they progress.
Four hundred thirty-one individuals with asymptomatic genetic FTD (n = 114), genetic and sporadic bvFTD (n = 317), and 163 asymptomatic non-carrier controls were enrolled. In sub-samples, we investigated empathy measured by the informant-based Interpersonal Reactivity Index (IRI) at each disease stage and over time (n = 91), and its correspondence to underlying atrophy (n = 51).
Empathic concern (estimate = 4.38, 95% confidence interval [CI] = 2.79, 5.97; p < 0.001) and perspective taking (estimate = 5.64, 95% CI = 3.81, 7.48; p < 0.001) scores declined between the asymptomatic and very mild symptomatic stages regardless of pathogenic variant status. More rapid loss of empathy corresponded with subcortical atrophy.
Loss of empathy is an early and progressive symptom of bvFTD that is measurable by IRI informant ratings and can be used to monitor behavior in neuropsychiatry practice and treatment trials.
Four hundred thirty-one individuals with asymptomatic genetic FTD (n = 114), genetic and sporadic bvFTD (n = 317), and 163 asymptomatic non-carrier controls were enrolled. In sub-samples, we investigated empathy measured by the informant-based Interpersonal Reactivity Index (IRI) at each disease stage and over time (n = 91), and its correspondence to underlying atrophy (n = 51).
Empathic concern (estimate = 4.38, 95% confidence interval [CI] = 2.79, 5.97; p < 0.001) and perspective taking (estimate = 5.64, 95% CI = 3.81, 7.48; p < 0.001) scores declined between the asymptomatic and very mild symptomatic stages regardless of pathogenic variant status. More rapid loss of empathy corresponded with subcortical atrophy.
Loss of empathy is an early and progressive symptom of bvFTD that is measurable by IRI informant ratings and can be used to monitor behavior in neuropsychiatry practice and treatment trials.
摘要：
背景：同理心依赖于在行为变异额颞叶痴呆（bvFTD）中选择性脆弱的额扣环和颞叶网络。这项研究模拟了疾病过程中移情变化何时开始，以及他们如何进步。
方法：四百三十一例无症状遗传FTD（n=114），遗传和散发性bvFTD(n=317)，纳入163名无症状非携带者对照.在子样本中，我们调查了在每个疾病阶段和一段时间（n=91），通过基于信息的人际反应指数（IRI）测量的同理心，及其与潜在萎缩的对应关系(n=51)。
结果：共情关注（估计值=4.38，95％置信区间[CI]=2.79，5.97；p<0.001）和观点接受（估计值=5.64，95％CI=3.81，7.48；p<0.001）评分在无症状和非常轻度症状阶段之间下降，而与致病变异状态无关。同理心的更快丧失与皮质下萎缩相对应。
结论：失去同理心是bvFTD的早期和进行性症状，可通过IRI信息评级来衡量，可用于监测神经精神病学实践和治疗试验中的行为。
方法：四百三十一例无症状遗传FTD（n=114），遗传和散发性bvFTD(n=317)，纳入163名无症状非携带者对照.在子样本中，我们调查了在每个疾病阶段和一段时间（n=91），通过基于信息的人际反应指数（IRI）测量的同理心，及其与潜在萎缩的对应关系(n=51)。
结果：共情关注（估计值=4.38，95％置信区间[CI]=2.79，5.97；p<0.001）和观点接受（估计值=5.64，95％CI=3.81，7.48；p<0.001）评分在无症状和非常轻度症状阶段之间下降，而与致病变异状态无关。同理心的更快丧失与皮质下萎缩相对应。
结论：失去同理心是bvFTD的早期和进行性症状，可通过IRI信息评级来衡量，可用于监测神经精神病学实践和治疗试验中的行为。
