Abstract:
In recent years scientific research has established that the nervous and immune systems have shared molecular signaling components. Proteins native to immune cells, which are also found in the brain, have neuronal functions in the nervous system where they affect synaptic plasticity, axonal regeneration, neurogenesis, and neurotransmission. Certain native immune molecules like major histocompatibility complex I (MHC-I), paired immunoglobulin receptor B (PirB), toll-like receptor (TLR), cluster of differentiation-3 zeta (CD3ζ), CD4 co-receptor, and T-cell receptor beta (TCR-β) expression in neurons have been extensively documented. In this review, we provide our opinion and discussed the possible roles of T-cell receptor beta subunits in modulating the function of neurons in the central nervous system. Based on the previous findings of Syken and Shatz., 2003; Nishiyori et al., 2004; Rodriguez et., 1993 and Komal et., 2014; we discuss whether restrictive expression of TCR-β subunits in selected brain regions could be involved in the pathology of neurological disorders and whether their aberrant enhancement in expression may be considered as a suitable biomarker for aging or neurodegenerative diseases like Huntington\'s disease (HD).
摘要:
近年来,科学研究已经确定神经和免疫系统具有共享的分子信号传导成分。免疫细胞的天然蛋白质,它们也存在于大脑中,在神经系统中具有神经元功能,它们会影响突触可塑性,轴突再生,神经发生,和神经传递。某些天然免疫分子,如主要组织相容性复合物I(MHC-I),配对免疫球蛋白受体B(PirB),toll样受体(TLR),分化簇-3ζ(CD3ζ),CD4共受体,和T细胞受体β(TCR-β)在神经元中的表达已被广泛记录。在这次审查中,我们提供了我们的观点,并讨论了T细胞受体β亚基在调节中枢神经系统神经元功能中的可能作用。基于Syken和Shatz之前的发现。,2003;Nishiyori等人。,2004年;罗德里格斯等。,1993年和Komal等人。,2014年;我们讨论了在选定的大脑区域中TCR-β亚基的限制性表达是否可能与神经系统疾病的病理学有关,以及它们的表达异常增强是否可以被认为是衰老或神经退行性疾病如亨廷顿病(HD)的合适生物标志物。