PDF(Pubmed)
Abstract：
Hypertriglyceridemia-induced pancreatitis is a relatively common form of acute pancreatitis that may represent up to 10% of all etiologies of this condition. Due to its specific pathogenic mechanisms related to high serum triglyceride levels, different treatment options have been proposed, including insulin perfusion, heparin perfusion, and plasmapheresis. Although the superiority of plasmapheresis in this clinical setting has not been demonstrated in randomized clinical trials, many centers have reported its effectiveness and considered this as a possible alternative according to the current guidelines. We report a case of a young patient diagnosed with hypertriglyceridemia-induced pancreatitis that was successfully treated with plasmapheresis. Since complications associated with plasmapheresis are rare and other therapeutic options may not be so effective or safe, we believe that this should be a valid alternative treatment that may be offered to these patients. More studies are still needed to further evaluate its effectiveness and to elucidate if there is a subset of patients in whom treatment with plasmapheresis may be more beneficial.
摘要：
高甘油三酯血症引起的胰腺炎是一种相对常见的急性胰腺炎形式，可能占这种疾病所有病因的10％。由于其与高血清甘油三酯水平相关的特定致病机制，已经提出了不同的治疗方案，包括胰岛素灌注，肝素灌注，和血浆置换.尽管在随机临床试验中尚未证明血浆置换在这种临床环境中的优越性，许多中心已经报告了其有效性,并根据当前指南认为这是一种可能的替代方案.我们报告了一例诊断为高甘油三酯血症引起的胰腺炎的年轻患者，该患者已成功接受血浆置换治疗。由于与血浆置换相关的并发症很少见，其他治疗方案可能不那么有效或安全，我们认为，这应该是一个有效的替代治疗，可以提供给这些患者。仍需要更多的研究来进一步评估其有效性，并阐明是否有一部分患者使用血浆置换治疗可能更有益。
