PDF(Pubmed)
Abstract：
Stroke and cancer are two of the most common health problems. Moreover, stroke is more common in patients with cancer than in the normal population, due to coagulation problems. Knowing the etiology of stroke is important for determining treatment options. This study aimed to determine the relationship between ischemic lesion topographies using diffusion-weighted magnetic resonance imaging (MRI) and the etiology of stroke in patients with cancer.
All patients with ischemic stroke in the Bezmialem Stroke Registry over a 4- year period were retrospectively analyzed in this study. Patients with acute ischemic stroke and additional diagnoses of solid and active malignancy (excluding hematologic malignancies) were included in the analysis. We investigated whether there was a relationship between the etiology of patients with cancer-related stroke according to the stroke etiologic classification and the diffusion restriction patterns on MRI.
In this registry, 32 of 1472 patients were diagnosed as having active cancer. Fourteen patients were evaluated as having definite cardioembolism, eight patients as probable cardioembolism, and four patients had inadequate examinations. Only one patient was classified as having an atherothrombotic stroke. Isolated acute infarction was seen in 15 of 32 patients. In patients with multiple acute infarct areas (n=17), acute lesions characterized by micro embolisms in a single vessel area were detected in four patients, and acute lesions characterized by bilateral (anterior and/or posterior system) micro embolisms in more than one vessel area in 13 patients.
The most common etiology of stroke in patients with cancer was found to be embolic/ cardioembolic. This is important for the treatment plans for ischemic stroke in patients with cancer.
All patients with ischemic stroke in the Bezmialem Stroke Registry over a 4- year period were retrospectively analyzed in this study. Patients with acute ischemic stroke and additional diagnoses of solid and active malignancy (excluding hematologic malignancies) were included in the analysis. We investigated whether there was a relationship between the etiology of patients with cancer-related stroke according to the stroke etiologic classification and the diffusion restriction patterns on MRI.
In this registry, 32 of 1472 patients were diagnosed as having active cancer. Fourteen patients were evaluated as having definite cardioembolism, eight patients as probable cardioembolism, and four patients had inadequate examinations. Only one patient was classified as having an atherothrombotic stroke. Isolated acute infarction was seen in 15 of 32 patients. In patients with multiple acute infarct areas (n=17), acute lesions characterized by micro embolisms in a single vessel area were detected in four patients, and acute lesions characterized by bilateral (anterior and/or posterior system) micro embolisms in more than one vessel area in 13 patients.
The most common etiology of stroke in patients with cancer was found to be embolic/ cardioembolic. This is important for the treatment plans for ischemic stroke in patients with cancer.
摘要：
背景：中风和癌症是两种最常见的健康问题。此外，中风在癌症患者中比在正常人群中更常见，由于凝血问题。了解中风的病因对于确定治疗方案很重要。这项研究旨在确定使用扩散加权磁共振成像（MRI）的缺血性病变拓扑与癌症患者中风病因之间的关系。
患者和方法：本研究对Bezmialem卒中登记处4年的所有缺血性卒中患者进行回顾性分析。分析包括急性缺血性卒中和其他诊断为实体和活动性恶性肿瘤（不包括血液恶性肿瘤）的患者。根据卒中病因分类，我们调查了癌症相关卒中患者的病因与MRI弥散限制模式之间是否存在关系。
结果：在此注册表中，1472名患者中有32名被诊断为患有活动性癌症。14例患者被评估为有明确的心脏栓塞，八名患者可能是心源性栓塞,四名病人检查不充分。只有一名患者被归类为患有动脉粥样硬化血栓形成性中风。32例患者中有15例出现孤立的急性梗塞。在多个急性梗死区的患者中[n=17]，在四名患者中发现了以单血管区域微栓塞为特征的急性病变，13例患者的急性病变特征为双侧（前和/或后系统）一个以上血管区域的微栓塞。
结论：发现癌症患者中风的最常见病因是栓塞/心脏栓塞。这对癌症患者缺血性脑卒中的医治计划具有重要意义。
