Abstract：
BACKGROUND: Brain cancer is one of the most aggressive cancer types owing to poor treatment effects. Epidemiological studies have demonstrated that allergies may increase the disease risk. Therefore, this study evaluated the association between eczema and the risk of various brain cancers.
METHODS: We systematically searched the PubMed and Embase databases from their inception until June 23, 2022. Two reviewers independently reviewed and screened the articles, extracted data, assessed the study quality, and pooled the results. Stata software was used to generate pooled odds ratios and 95% confidence intervals (CIs).
RESULTS: We included 20 studies comprising 5,117,222 patients that investigated the relationship between eczema and brain cancer. Eczema was significantly inversely associated with the risk of brain cancer (odds ratio [OR], 0.82; 95% CI, 0.77-0.87), glioma (OR, 0.53; 95% CI, 0.14-2.02), meningioma (OR, 0.74; 95% CI, 0.66-0.84), and acoustic neuroma (OR, 0.60; 95% CI, 0.41-0.88). Interesting, The strong correlation between eczema and the reduced risk of brain cancer was observed in people over 16 years old (OR, 0.79; 95% CI, 0.71-0.88), but not in those under 16 years old (OR, 0.94; 95% CI, 0.79-1.11). In addition, subgroup analyses found that eczema significantly decreased the glioma risk in Europeans (OR, 0.73; 95% CI, 0.65-0.82) but not Australians (OR, 0.53; 95% CI, 0.14-2.02) or Americans (OR, 1.01; 95% CI, 0.69-1.46).
CONCLUSIONS: Eczema may be considered as a potential protective factor of brain cancer in population aged over 16 years. However, this relationship requires verification using large-scale clinical data.
METHODS: We systematically searched the PubMed and Embase databases from their inception until June 23, 2022. Two reviewers independently reviewed and screened the articles, extracted data, assessed the study quality, and pooled the results. Stata software was used to generate pooled odds ratios and 95% confidence intervals (CIs).
RESULTS: We included 20 studies comprising 5,117,222 patients that investigated the relationship between eczema and brain cancer. Eczema was significantly inversely associated with the risk of brain cancer (odds ratio [OR], 0.82; 95% CI, 0.77-0.87), glioma (OR, 0.53; 95% CI, 0.14-2.02), meningioma (OR, 0.74; 95% CI, 0.66-0.84), and acoustic neuroma (OR, 0.60; 95% CI, 0.41-0.88). Interesting, The strong correlation between eczema and the reduced risk of brain cancer was observed in people over 16 years old (OR, 0.79; 95% CI, 0.71-0.88), but not in those under 16 years old (OR, 0.94; 95% CI, 0.79-1.11). In addition, subgroup analyses found that eczema significantly decreased the glioma risk in Europeans (OR, 0.73; 95% CI, 0.65-0.82) but not Australians (OR, 0.53; 95% CI, 0.14-2.02) or Americans (OR, 1.01; 95% CI, 0.69-1.46).
CONCLUSIONS: Eczema may be considered as a potential protective factor of brain cancer in population aged over 16 years. However, this relationship requires verification using large-scale clinical data.
摘要：
背景：由于治疗效果差，脑癌是最具侵袭性的癌症类型之一。流行病学研究表明，过敏可能会增加疾病的风险。因此,这项研究评估了湿疹与各种脑癌风险之间的关系。
方法：我们系统地搜索了PubMed和Embase数据库，从它们开始到2022年6月23日。两名审稿人独立审查和筛选文章，提取的数据，评估研究质量，并汇总了结果。使用Stata软件生成合并比值比和95%置信区间(CI)。
结果：我们纳入了20项研究，包括5,117,222名患者，调查了湿疹与脑癌之间的关系。湿疹与脑癌风险呈显著负相关(比值比[OR]，0.82；95%CI，0.77-0.87），胶质瘤（OR，0.53；95%CI，0.14-2.02），脑膜瘤（或，0.74；95%CI，0.66-0.84），和听神经瘤(或，0.60；95%CI，0.41-0.88）。有趣,在16岁以上的人群中观察到湿疹与脑癌风险降低之间的强相关性（OR，0.79；95%CI，0.71-0.88），但不是16岁以下的人(或者，0.94；95%CI，0.79-1.11）。此外,亚组分析发现，湿疹显著降低了欧洲人的神经胶质瘤风险(OR，0.73；95%CI，0.65-0.82)，但不是澳大利亚人(OR，0.53；95%CI，0.14-2.02)或美国人(OR，1.01；95%CI，0.69-1.46）。
结论：湿疹可能是16岁以上人群脑癌的潜在保护因素。然而,这种关系需要使用大规模临床数据进行验证.
方法：我们系统地搜索了PubMed和Embase数据库，从它们开始到2022年6月23日。两名审稿人独立审查和筛选文章，提取的数据，评估研究质量，并汇总了结果。使用Stata软件生成合并比值比和95%置信区间(CI)。
结果：我们纳入了20项研究，包括5,117,222名患者，调查了湿疹与脑癌之间的关系。湿疹与脑癌风险呈显著负相关(比值比[OR]，0.82；95%CI，0.77-0.87），胶质瘤（OR，0.53；95%CI，0.14-2.02），脑膜瘤（或，0.74；95%CI，0.66-0.84），和听神经瘤(或，0.60；95%CI，0.41-0.88）。有趣,在16岁以上的人群中观察到湿疹与脑癌风险降低之间的强相关性（OR，0.79；95%CI，0.71-0.88），但不是16岁以下的人(或者，0.94；95%CI，0.79-1.11）。此外,亚组分析发现，湿疹显著降低了欧洲人的神经胶质瘤风险(OR，0.73；95%CI，0.65-0.82)，但不是澳大利亚人(OR，0.53；95%CI，0.14-2.02)或美国人(OR，1.01；95%CI，0.69-1.46）。
结论：湿疹可能是16岁以上人群脑癌的潜在保护因素。然而,这种关系需要使用大规模临床数据进行验证.
