PDF(Pubmed)
Abstract：
UNASSIGNED: Cognitive impairment is common in the course of Parkinson\'s disease (PD) and displays a continuum from subjective cognitive impairment to dementia. Illuminating the pathophysiological processes associated with the continuum may help create follow-up and new treatment approaches. In this context, large-scale intrinsic connectivity networks are widely investigated to elucidate the neural processes underlying PD and are promising as non-invasive biomarkers. This systematic review aims to examine the alterations in large-scale intrinsic connectivity networks in the continuum of PD-associated cognitive impairment.
UNASSIGNED: ScienceDirect, Web of Science, and PubMed databases were searched with the specified keywords. The studies obtained as a result of this review were investigated by the PRISMA criteria, which were taken as a basis for the systematic review and writing of meta-analyses.
UNASSIGNED: A total of 974 studies were obtained from three databases. Twenty studies were included in the systematic review based on predetermined eligibility criteria. Among the large-scale connectivity networks examined in these studies, it was found that sensory-motor networks decreased their connectivity in the continuum of PD-associated cognitive impairment, and there were conflicting results in terms of cognitive networks.
UNASSIGNED: Well-designed longitudinal studies are needed to clarify the alterations in the intrinsic connectivity networks in the PD cognitive impairment continuum. In these studies, it is necessary to define the cognitive disorder groups well, to control the connectivity changes that may occur due to dopaminergic treatment, and to evaluate Parkinson\'s patients with subjective cognitive impairment and dementia within the continuum.
UNASSIGNED: ScienceDirect, Web of Science, and PubMed databases were searched with the specified keywords. The studies obtained as a result of this review were investigated by the PRISMA criteria, which were taken as a basis for the systematic review and writing of meta-analyses.
UNASSIGNED: A total of 974 studies were obtained from three databases. Twenty studies were included in the systematic review based on predetermined eligibility criteria. Among the large-scale connectivity networks examined in these studies, it was found that sensory-motor networks decreased their connectivity in the continuum of PD-associated cognitive impairment, and there were conflicting results in terms of cognitive networks.
UNASSIGNED: Well-designed longitudinal studies are needed to clarify the alterations in the intrinsic connectivity networks in the PD cognitive impairment continuum. In these studies, it is necessary to define the cognitive disorder groups well, to control the connectivity changes that may occur due to dopaminergic treatment, and to evaluate Parkinson\'s patients with subjective cognitive impairment and dementia within the continuum.
摘要：
未经证实：认知损害在帕金森病（PD）的病程中很常见，表现为从主观认知损害到痴呆的连续性。照亮与连续体相关的病理生理过程可能有助于创建后续和新的治疗方法。在这种情况下，大规模的内在连接网络被广泛研究以阐明PD背后的神经过程,并有望作为非侵入性生物标志物。本系统综述旨在研究PD相关认知障碍连续体中大规模内在连接网络的变化。
未经批准：ScienceDirect，WebofScience,并使用指定的关键字搜索PubMed数据库。通过本综述获得的研究是通过PRISMA标准进行调查的，作为系统回顾和撰写荟萃分析的基础。
UNASSIGNED：共有974项研究来自三个数据库。根据预定的资格标准，将20项研究纳入系统评价。在这些研究中检查的大规模连接网络中，研究发现，在PD相关认知障碍的连续体中，感觉运动网络降低了它们的连通性，在认知网络方面存在矛盾的结果。
未经评估：需要精心设计的纵向研究来阐明PD认知障碍连续体中内在连接网络的改变。在这些研究中,有必要很好地界定认知障碍群体，为了控制可能由于多巴胺能治疗而发生的连通性变化，并在连续体中评估帕金森病患者的主观认知障碍和痴呆。
未经批准：ScienceDirect，WebofScience,并使用指定的关键字搜索PubMed数据库。通过本综述获得的研究是通过PRISMA标准进行调查的，作为系统回顾和撰写荟萃分析的基础。
UNASSIGNED：共有974项研究来自三个数据库。根据预定的资格标准，将20项研究纳入系统评价。在这些研究中检查的大规模连接网络中，研究发现，在PD相关认知障碍的连续体中，感觉运动网络降低了它们的连通性，在认知网络方面存在矛盾的结果。
未经评估：需要精心设计的纵向研究来阐明PD认知障碍连续体中内在连接网络的改变。在这些研究中,有必要很好地界定认知障碍群体，为了控制可能由于多巴胺能治疗而发生的连通性变化，并在连续体中评估帕金森病患者的主观认知障碍和痴呆。
