UNASSIGNED: A 43-year-old woman was diagnosed with a nodular stage IIB melanoma of her left thigh, according to the AJCC 8th edition (T3bN0M0). The woman was treated with adjuvant nivolumab. She stopped the treatment after 4 infusions due to thrombopenia. Three months later, she developed facial and leg edema and ascites due to capillary leak syndrome. The CLS was associated with chylothorax and elevated vascular endothelial growth factor. The patient was initially treated with several pleural puncturing and steroids. CLS and chylothorax progressively decreased with intravenous immunoglobulins and fat-free diet without recurrence of melanoma at one-year follow-up.
UNASSIGNED: CLS is a rare and potentially life-threatening AE of ICIs such as anti-PD1. This AE may be associated with chylothorax probably related to lymphatic permeability induced by anti-PD1.
未经证实:一名43岁的女性被诊断为左大腿结节性IIB期黑色素瘤,根据AJCC第8版(T3bN0M0)。该妇女用佐剂nivolumab治疗。由于血栓减少症,她在4次输液后停止了治疗。三个月后,由于毛细血管渗漏综合征,她出现了面部和腿部水肿和腹水。CLS与乳糜胸和血管内皮生长因子升高有关。患者最初接受了几次胸膜穿刺和类固醇治疗。在一年的随访中,静脉注射免疫球蛋白和无脂饮食使CLS和乳糜胸逐渐减少,而黑色素瘤没有复发。
未经证实:CLS是一种罕见且可能危及生命的ICIsAE,如抗PD1。这种AE可能与乳糜胸有关,可能与抗PD1诱导的淋巴通透性有关。