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Abstract：
This investigation mainly explores the roles of actin-related protein 2 (ACTR2) in diffuse large B-cell lymphoma (DLBCL). We first assessed the level of ACTR2 and its association with the overall survival (OS) of DLBCL. The results indicated that ACTR2 was upregulated in DLBCL and was associated with unfavorable prognosis of DLBCL. Next, the effect of ACTR2 knockdown or overexpression on DLBCL was evaluated in vitro. Our investigation revealed that ACTR2 depletion inhibited the malignant behaviors of DLBCL cells; whereas, ACTR2 abundance promoted those behaviors. Besides, ACTR2 activated the Wnt signaling in DLBCL and exerted its oncogenic influence on DLBCL through Wnt signaling in vitro and in vivo. To summarize, our study implicated that ACTR2 was a promising therapeutic target for DLBCL, which might become a novel direction to improve our understanding on DLBCL.
摘要：
本研究主要探讨肌动蛋白相关蛋白2（ACTR2）在弥漫性大B细胞淋巴瘤（DLBCL）中的作用。我们首先评估了ACTR2水平及其与DLBCL总生存期(OS)的关系。结果表明，ACTR2在DLBCL中上调，并与DLBCL的不良预后有关。接下来,在体外评估了ACTR2敲低或过表达对DLBCL的影响。我们的研究表明，ACTR2耗竭抑制了DLBCL细胞的恶性行为；然而，ACTR2丰度促进了这些行为。此外,ACTR2在体外和体内激活DLBCL中的Wnt信号并通过Wnt信号对DLBCL产生致癌影响。总结一下,我们的研究暗示ACTR2是DLBCL的一个有希望的治疗靶点，这可能成为提高我们对DLBCL理解的新方向。
