Case report: Nocardia gipuzkoensis infection in an immunocompetent patient diagnosed by metagenomic next-generation sequencing and whole genome sequencing.

病例报告 ： 通过宏基因组下一代测序和全基因组测序诊断的具有免疫能力的患者中的诺卡氏菌 gipuzkoensis 感染。

• 影响指数: 8.786
• 发表时间: 2022
• 来源期刊: Front Immunol
• DOI: 10.3389/fimmu.2022.1053914
• PMID: 36569853
• 文章类型: Case Reports
• 中科院分区: Q2
• 方向: 医学
• 作者列表: Liu C,Yang J,Huang H,Zhan S,Xia X

关键词: antibiotic susceptibility; case report; metagenomic next-generation sequencing; nocardiosis; pathogen identification; whole genome sequencing

Mesh: Female; Humans; Young Adult; Adult; Nocardia Infections / diagnosis drug therapy; Nocardia / genetics; Sulfamethoxazole / therapeutic use; High-Throughput Nucleotide Sequencing; Whole Genome Sequencing

Abstract

The infection of Nocardia gipuzkoensis is a relatively uncommon form of pulmonary nocardiosis seen in clinical patients. In general, nocardiosis tends to occur in patients with immune deficiency. Here, we report a 23-year-old female who was admitted to the hospital due to cough and sputum production over 10 years, diagnosed with bronchiectasis. The N. gipuzkoensis infection was identified by metagenomic next-generation sequencing and whole genome sequencing. Imipenem/cilastatin and compound sulfamethoxazole tablets were used to control the infection and the pulmonary inflammation subsided gradually.

摘要

在临床患者中，诺卡氏菌感染是一种相对罕见的肺诺卡氏菌病。总的来说,免疫缺陷患者往往会发生诺卡病。这里,我们报告了一名23岁的女性，她因咳嗽和咳痰而住院超过10年，诊断为支气管扩张.通过宏基因组下一代测序和全基因组测序鉴定了Gipuzkoensis感染。采用亚胺培南/西司他丁和复方磺胺甲恶唑片控制感染,肺部炎症逐渐消退。