关键词： AEC, airway epithelial cells AM, alveolar macrophages BAL, bronchial alveolar lavage CC16, Clara cell protein 16 CM, cardiomyocyte CNS, central nervous system COPD, chronic obstructive pulmonary disease CS, cigarette smoke CSC, Cancer Stem Cell CYP, cytochrome P450 E-cigarettes E2F1, E2F transcription factor 1 EMT, epithelial-to-mesenchymal transition ENDS, electronic nicotine delivery system EVALI EVALI, e-cigarette or vaping product use-associated lung injury FDA, Food and Drug Administration FOXO3, forkhead box O3 HNSCC, head and neck squamous cancer cells HUVEC, human umbilical vein endothelial cells Health risks IL, interleukin LDL, low-density lipoprotein MCP-1, monocyte chemoattractant protein-1 MMP9, matrix metallopeptidase 9 MPP, Mycoplasma pneumoniae pneumonia NET, neutrophil extracellular traps NK, natural killer NOX, NADPH oxidase NQO-1, NAD(P)H quinone dehydrogenase 1 Nicotine Nrf2, nuclear factor erythroid 2-related factor 2 OGG1/2, 8-oxoguanine glycosylase OS, oxidative stress Oct4,, Octamer-binding transcription factor 4 PAFR, platelet-activating factor receptor PAHs, polycyclic aromatic hydrocarbons PG, propylene glycol ROS, reactive oxygen species Sox2,, SRY (sex determining region Y)-box 2 THC, Tetrahydrocannabinol TNF‐α, tumor necrosis factor alpha VAPI, vaping-associated pulmonary injury VG, vegetable glycerin Vaping XPC, xeroderma pigmentosum complementation group C Yap1, Yes associated protein 1 ZEB, zinc finger E-box binding homeobox ZO-1, zonula occludens-1 e-cigarettes, electronic cigarettes e-liquid, e-cigarette liquid e-vapor, e-cigarette vapor iPSC-EC, induced pluripotent stem cell-derived endothelial cells pAMPK, phospho-AMP-activated protein kinase

来  源：   DOI：10.1016/j.toxrep.2022.06.006   PDF(Pubmed)

Abstract：
In recent years, new nicotine delivery methods have emerged, and many users are choosing electronic cigarettes (e-cigarettes) over traditional tobacco cigarettes. E-cigarette use is very popular among adolescents, with more than 3.5 million currently using these products in the US. Despite the increased prevalence of e-cigarette use, there is limited knowledge regarding the health impact of e-cigarettes on the general population. Based on published findings by others, E-cigarette is associated with lung injury outbreak, which increased health and safety concerns related to consuming this product. Different components of e-cigarettes, including food-safe liquid solvents and flavorings, can cause health issues related to pneumonia, pulmonary injury, and bronchiolitis. In addition, e-cigarettes contain alarmingly high levels of carcinogens and toxicants that may have long-lasting effects on other organ systems, including the development of neurological manifestations, lung cancer, cardiovascular disorders, and tooth decay. Despite the well- documented potential for harm, e-cigarettes do not appear to increase susceptibility to SARS-CoV- 2 infection. Furthermore, some studies have found that e-cigarette users experience improvements in lung health and minimal adverse effects. Therefore, more studies are needed to provide a definitive conclusion on the long-term safety of e-cigarettes. The purpose of this review is to inform the readers about the possible health-risks associated with the use of e-cigarettes, especially among the group of young and young-adults, from a molecular biology point of view.
摘要：
近年来,新的尼古丁输送方法已经出现，和许多用户正在选择电子香烟（电子香烟）而不是传统的烟草香烟。电子烟的使用在青少年中非常流行，目前在美国有超过350万人使用这些产品。尽管电子烟的使用越来越普遍，关于电子烟对一般人群的健康影响的知识有限。根据其他人发表的发现，电子烟与肺损伤爆发有关，这增加了与消费该产品相关的健康和安全问题。电子烟的不同成分，包括食品安全液体溶剂和调味剂，会导致与肺炎有关的健康问题，肺损伤，还有细支气管炎.此外,电子烟含有惊人的高水平的致癌物质和有毒物质，可能对其他器官系统有长期的影响，包括神经表现的发展，肺癌,心血管疾病,和蛀牙。尽管有据可查的潜在危害，电子烟似乎不会增加对SARS-CoV-2感染的易感性。此外，一些研究发现，电子烟使用者的肺部健康状况有所改善，副作用最小。因此,需要更多的研究来提供关于电子烟长期安全性的明确结论.这篇评论的目的是让读者了解与使用电子烟相关的可能的健康风险，特别是在年轻人和年轻人群体中，从分子生物学的角度来看。
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