PDF(Pubmed)
Abstract：
Healthcare for adolescents and birth defects (BD) prevention are highlighted public health issues. The epidemiology of birth defects in teenage pregnancies has not been studied extensively.
To investigate the prevalence trend and spectrum of BDs among teenage mothers.
This observational study covered all births registered in the BD surveillance system in Zhejiang Province, China, during 2012-2018. The annual change in the prevalence of BDs among adolescent mothers was estimated. Crude relative ratios using the BD categories in teenage pregnancies were calculated and compared with those in women aged 25-29 years.
Overall, 54,571 BD cases among 1,910,977 births were included in this study, resulting in an overall prevalence of 234.64 to 409.07 per 10,000 births from 2012 to 2018 (P trend < 0.001) in total population. The prevalence of birth defects in teenage pregnancies increased from 247.19 to 387.73 per 10,000 births in 2012-2018 (P trend = 0.024). The risks of neural tube defects (relative risk [RR] = 3.15, 95% confidence interval [CI] 2.56, 3.87), gastroschisis (RR = 7.02, 95% CI 5.09, 9.69), and multiple birth defects (RR=1.27, 95% CI 1.07, 1.52) were higher in teenage pregnancies than those in women aged 25-29 years.
We found a distinctive spectrum of BDs, with higher proportions of fatal or multiple anomalies in infants born to teenage mothers than in those born to adults aged 25-29 years. These results emphasize the importance of providing adolescents with better access to reproductive and prenatal care.
To investigate the prevalence trend and spectrum of BDs among teenage mothers.
This observational study covered all births registered in the BD surveillance system in Zhejiang Province, China, during 2012-2018. The annual change in the prevalence of BDs among adolescent mothers was estimated. Crude relative ratios using the BD categories in teenage pregnancies were calculated and compared with those in women aged 25-29 years.
Overall, 54,571 BD cases among 1,910,977 births were included in this study, resulting in an overall prevalence of 234.64 to 409.07 per 10,000 births from 2012 to 2018 (P trend < 0.001) in total population. The prevalence of birth defects in teenage pregnancies increased from 247.19 to 387.73 per 10,000 births in 2012-2018 (P trend = 0.024). The risks of neural tube defects (relative risk [RR] = 3.15, 95% confidence interval [CI] 2.56, 3.87), gastroschisis (RR = 7.02, 95% CI 5.09, 9.69), and multiple birth defects (RR=1.27, 95% CI 1.07, 1.52) were higher in teenage pregnancies than those in women aged 25-29 years.
We found a distinctive spectrum of BDs, with higher proportions of fatal or multiple anomalies in infants born to teenage mothers than in those born to adults aged 25-29 years. These results emphasize the importance of providing adolescents with better access to reproductive and prenatal care.
摘要：
未经评估：青少年医疗保健和出生缺陷（BD）预防是重点关注的公共卫生问题。尚未广泛研究少女怀孕中出生缺陷的流行病学。
UNASSIGNED：调查少女母亲中BD的流行趋势和频谱。
UNASSIGNED：这项观察性研究涵盖了浙江省BD监测系统中登记的所有新生儿，中国,2012-2018年。估计了青春期母亲中BD患病率的年度变化。计算了少女怀孕中使用BD类别的粗相对比率，并将其与25-29岁女性的相对比率进行了比较。
未经评估：总的来说，这项研究纳入了1,910,977例新生儿中的54,571例BD病例，导致2012年至2018年总人口中每10,000名新生儿的总体患病率为234.64~409.07(P趋势<0.001).2012-2018年，少女怀孕中出生缺陷的患病率从每10,000名婴儿247.19增加到387.73（P趋势=0.024）。神经管缺陷的风险（相对风险[RR]=3.15，95%置信区间[CI]2.56，3.87），腹裂(RR=7.02，95%CI5.09，9.69)，和多胎出生缺陷(RR=1.27,95%CI1.07,1.52)在少女怀孕中高于25-29岁女性。
未经证实：我们发现了独特的BD谱，与25-29岁的成年人相比，少女母亲所生婴儿的致命或多重异常比例更高。这些结果强调了为青少年提供更好的生殖和产前保健的重要性。
UNASSIGNED：调查少女母亲中BD的流行趋势和频谱。
UNASSIGNED：这项观察性研究涵盖了浙江省BD监测系统中登记的所有新生儿，中国,2012-2018年。估计了青春期母亲中BD患病率的年度变化。计算了少女怀孕中使用BD类别的粗相对比率，并将其与25-29岁女性的相对比率进行了比较。
未经评估：总的来说，这项研究纳入了1,910,977例新生儿中的54,571例BD病例，导致2012年至2018年总人口中每10,000名新生儿的总体患病率为234.64~409.07(P趋势<0.001).2012-2018年，少女怀孕中出生缺陷的患病率从每10,000名婴儿247.19增加到387.73（P趋势=0.024）。神经管缺陷的风险（相对风险[RR]=3.15，95%置信区间[CI]2.56，3.87），腹裂(RR=7.02，95%CI5.09，9.69)，和多胎出生缺陷(RR=1.27,95%CI1.07,1.52)在少女怀孕中高于25-29岁女性。
未经证实：我们发现了独特的BD谱，与25-29岁的成年人相比，少女母亲所生婴儿的致命或多重异常比例更高。这些结果强调了为青少年提供更好的生殖和产前保健的重要性。
