Abstract:
The incidence of renal disease is gradually increasing worldwide, and this condition has become a major public health problem because it is a trigger for many other chronic diseases. Cell therapies using multipotent mesenchymal stromal cells, hematopoietic stem cells, macrophages, and other cell types have been used to induce regeneration and provide a cure for acute and chronic kidney disease in experimental models. This review describes the advances in cell therapy protocols applied to acute and chronic kidney injuries and the attempts to apply these treatments in a clinical setting.
摘要:
肾脏疾病的发病率在世界范围内逐渐增加,这种情况已经成为一个主要的公共卫生问题,因为它是许多其他慢性疾病的触发因素。使用多能间充质基质细胞的细胞疗法,造血干细胞,巨噬细胞,和其他细胞类型已被用于诱导再生,并在实验模型中提供治疗急性和慢性肾脏疾病的方法。这篇综述描述了应用于急性和慢性肾损伤的细胞治疗方案的进展,以及在临床环境中应用这些治疗方法的尝试。