PDF(Pubmed)
Abstract：
UNASSIGNED: Olfactory dysfunction may be an early symptom of degenerative neurological disorders such as mild cognitive impairment (MCI), which may progress to cognitive decline and Alzheimer\'s disease (AD). We investigated the relationship between cognitive decline and olfactory dysfunction in healthy controls and patients with MCI or AD using the DEmentia Screening Kit (DESK), an olfactory identification assessment tool designed for Japanese populations.
UNASSIGNED: In this multicenter, open-label, interventional study conducted from 16 September 2020 to 30 April 2021, participants underwent olfactory tests using the DESK tool. This included 10 odorants at two concentrations (weak/strong) including toothpaste, butter, and India ink.
UNASSIGNED: Among 223 participants, 100, 61, and 62 were healthy controls, MCI patients, and AD patients (mean ages, 57.4, 72.8, and 76.3 years; total DESK olfaction scores, 18.4, 14.7, and 7.4), respectively. Significant differences in total olfaction scores were observed between groups (healthy controls vs MCI, healthy controls vs AD, and MCI vs AD). Significant between-group total score differences were shown for olfaction scores with both the 10 strong and 10 weak odorant varieties.
UNASSIGNED: The DESK tool may discriminate between healthy individuals and those with MCI or AD, facilitating early screening for cognitive decline among Japanese patients, although the effect of age on DESK olfaction scores has not been fully explored.
UNASSIGNED: In this multicenter, open-label, interventional study conducted from 16 September 2020 to 30 April 2021, participants underwent olfactory tests using the DESK tool. This included 10 odorants at two concentrations (weak/strong) including toothpaste, butter, and India ink.
UNASSIGNED: Among 223 participants, 100, 61, and 62 were healthy controls, MCI patients, and AD patients (mean ages, 57.4, 72.8, and 76.3 years; total DESK olfaction scores, 18.4, 14.7, and 7.4), respectively. Significant differences in total olfaction scores were observed between groups (healthy controls vs MCI, healthy controls vs AD, and MCI vs AD). Significant between-group total score differences were shown for olfaction scores with both the 10 strong and 10 weak odorant varieties.
UNASSIGNED: The DESK tool may discriminate between healthy individuals and those with MCI or AD, facilitating early screening for cognitive decline among Japanese patients, although the effect of age on DESK olfaction scores has not been fully explored.
摘要：
未经证实：嗅觉功能障碍可能是退行性神经系统疾病的早期症状，例如轻度认知障碍（MCI）。这可能会进展为认知能力下降和阿尔茨海默病（AD）。我们使用Dementia筛查试剂盒（DESK）调查了健康对照组和MCI或AD患者的认知功能下降与嗅觉功能障碍之间的关系，为日本人群设计的嗅觉识别评估工具。
未经评估：在此多中心中，开放标签，从2020年9月16日至2021年4月30日进行的介入研究，参与者使用DESK工具进行了嗅觉测试。其中包括两种浓度（弱/强）的10种气味剂，包括牙膏，黄油,印度墨水
未经评估：在223名参与者中，100、61和62是健康对照，MCI患者,和AD患者(平均年龄，57.4、72.8和76.3年；DESK嗅觉总分，18.4、14.7和7.4)，分别。组间总嗅觉评分有显著差异(健康对照vsMCI,健康对照vsAD,和MCIvsAD)。10个强气味品种和10个弱气味品种的嗅觉得分均显示出明显的组间总分差异。
未经评估：DESK工具可以区分健康个体和患有MCI或AD的个体，促进日本患者早期筛查认知能力下降，尽管年龄对DESK嗅觉评分的影响尚未得到充分探讨。
未经评估：在此多中心中，开放标签，从2020年9月16日至2021年4月30日进行的介入研究，参与者使用DESK工具进行了嗅觉测试。其中包括两种浓度（弱/强）的10种气味剂，包括牙膏，黄油,印度墨水
未经评估：在223名参与者中，100、61和62是健康对照，MCI患者,和AD患者(平均年龄，57.4、72.8和76.3年；DESK嗅觉总分，18.4、14.7和7.4)，分别。组间总嗅觉评分有显著差异(健康对照vsMCI,健康对照vsAD,和MCIvsAD)。10个强气味品种和10个弱气味品种的嗅觉得分均显示出明显的组间总分差异。
未经评估：DESK工具可以区分健康个体和患有MCI或AD的个体，促进日本患者早期筛查认知能力下降，尽管年龄对DESK嗅觉评分的影响尚未得到充分探讨。
