UNASSIGNED: In this multicenter, open-label, interventional study conducted from 16 September 2020 to 30 April 2021, participants underwent olfactory tests using the DESK tool. This included 10 odorants at two concentrations (weak/strong) including toothpaste, butter, and India ink.
UNASSIGNED: Among 223 participants, 100, 61, and 62 were healthy controls, MCI patients, and AD patients (mean ages, 57.4, 72.8, and 76.3 years; total DESK olfaction scores, 18.4, 14.7, and 7.4), respectively. Significant differences in total olfaction scores were observed between groups (healthy controls vs MCI, healthy controls vs AD, and MCI vs AD). Significant between-group total score differences were shown for olfaction scores with both the 10 strong and 10 weak odorant varieties.
UNASSIGNED: The DESK tool may discriminate between healthy individuals and those with MCI or AD, facilitating early screening for cognitive decline among Japanese patients, although the effect of age on DESK olfaction scores has not been fully explored.
未经评估:在此多中心中,开放标签,从2020年9月16日至2021年4月30日进行的介入研究,参与者使用DESK工具进行了嗅觉测试。其中包括两种浓度(弱/强)的10种气味剂,包括牙膏,黄油,印度墨水
未经评估:在223名参与者中,100、61和62是健康对照,MCI患者,和AD患者(平均年龄,57.4、72.8和76.3年;DESK嗅觉总分,18.4、14.7和7.4),分别。组间总嗅觉评分有显著差异(健康对照vsMCI,健康对照vsAD,和MCIvsAD)。10个强气味品种和10个弱气味品种的嗅觉得分均显示出明显的组间总分差异。
未经评估:DESK工具可以区分健康个体和患有MCI或AD的个体,促进日本患者早期筛查认知能力下降,尽管年龄对DESK嗅觉评分的影响尚未得到充分探讨。