来自龙胆菌的 Bellidifolin ( Michx 。) Hulten 通过 PI3K - Akt 信号通路保护 H9c2 细胞免受过氧化氢诱导的损伤。
关键词: ALT, alanine aminotransferase AMPK, AMP-activated protein kinase Akt1, protein kinase B1 BP, biological processes Bellidifolin CC, cellular components CK, creatine kinase DEGs, differentially expressed genes G. acuta, Gentianella acuta(Michx.) Hulten GO, gene ontology GSH-Px, glutathione peroxidase GSK-3β, glycogen synthase kinase-3β H2O2-induced injury H9c2, rat myocardial IL-6, interleukin 6 KEGG, kyoto encyclopedia of genes and genomes LDH, lactate dehydrogenase Liquid chromatography-mass spectrometry MF, molecular functions Network pharmacology Oxidative stress PDB, protein data bank PPI, protein-protein interaction Protective effect ROS, reactive oxygen species SOD, superoxide dismutase TNF, tumor necrosis factor TP53, tumor protein P53 VEGFA, vascular endothelial growth factor A cAMP, cyclic adenosine monophosphate qRT-PCR, quantitative reverse transcription PCR
来 源:
DOI:10.1016/j.toxrep.2022.08.006
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