Abstract：
OBJECTIVE: To evaluate the imaging quality of a synthetic phase-sensitive inversion recovery (SyPSIR) vessel and to add value to T2-weighted imaging (T2WI) for extramural venous invasion (EMVI) detection in patients with rectal cancer.
METHODS: Participants in this retrospective study underwent preoperative synthetic MRI between October 2020 and April 2022. SyPSIR image reconstruction was performed with a single inversion time of 10 ms. A junior and a senior radiologist evaluated the imaging quality, including overall imaging quality scores, motion artifact scores, and relative image signal intensity contrast between the tumor and peritumoral vessels (SItumor-vessel), of both T2WI and SyPSIR vessels. Differences in imaging quality between the two methods were assessed using the Wilcoxon signed-rank test and two-sample t-test. EMVI scores were recorded for T2WI and T2WI+SyPSIR vessel. The area under the receiver operating characteristic curve (AUC) was calculated to evaluate the diagnostic performance.
RESULTS: A total of 106 patients (35 EMVI+ and 71 EMVI-) were evaluated. There were no statistically significant differences in the overall image quality scores, motion artifacts, or SItumor-vessel (p = 0.08-0.93) between the T2WI and SyPSIR vessels. On combining T2WI and SyPSIR vessels, the AUC for pathological EMVI+ diagnoses increased from 0.65 to 0.88 for the junior radiologist and from 0.86 to 0.96 for the senior radiologist. Furthermore, the sensitivity of the analyses by junior and senior radiologists increased from 0.40 to 0.77 and 0.49 to 0.86, respectively.
CONCLUSIONS: A SyPSIR vessel can provide additional information to improve the diagnostic efficiency of pathological EMVI in rectal cancer, which may be beneficial for individualized clinical treatment.
CONCLUSIONS: • SyPSIR vessel and T2WI had similar imaging quality. • EMVI evaluation in SyPSIR vessel has a high inter-observer agreement. • The SyPSIR vessel has the potential to improve the diagnostic efficiency of EMVI detection in rectal cancer.
METHODS: Participants in this retrospective study underwent preoperative synthetic MRI between October 2020 and April 2022. SyPSIR image reconstruction was performed with a single inversion time of 10 ms. A junior and a senior radiologist evaluated the imaging quality, including overall imaging quality scores, motion artifact scores, and relative image signal intensity contrast between the tumor and peritumoral vessels (SItumor-vessel), of both T2WI and SyPSIR vessels. Differences in imaging quality between the two methods were assessed using the Wilcoxon signed-rank test and two-sample t-test. EMVI scores were recorded for T2WI and T2WI+SyPSIR vessel. The area under the receiver operating characteristic curve (AUC) was calculated to evaluate the diagnostic performance.
RESULTS: A total of 106 patients (35 EMVI+ and 71 EMVI-) were evaluated. There were no statistically significant differences in the overall image quality scores, motion artifacts, or SItumor-vessel (p = 0.08-0.93) between the T2WI and SyPSIR vessels. On combining T2WI and SyPSIR vessels, the AUC for pathological EMVI+ diagnoses increased from 0.65 to 0.88 for the junior radiologist and from 0.86 to 0.96 for the senior radiologist. Furthermore, the sensitivity of the analyses by junior and senior radiologists increased from 0.40 to 0.77 and 0.49 to 0.86, respectively.
CONCLUSIONS: A SyPSIR vessel can provide additional information to improve the diagnostic efficiency of pathological EMVI in rectal cancer, which may be beneficial for individualized clinical treatment.
CONCLUSIONS: • SyPSIR vessel and T2WI had similar imaging quality. • EMVI evaluation in SyPSIR vessel has a high inter-observer agreement. • The SyPSIR vessel has the potential to improve the diagnostic efficiency of EMVI detection in rectal cancer.
摘要：
目的：评估合成相敏反转恢复（SyPSIR）血管的成像质量，并增加T2加权成像（T2WI）对直肠癌患者壁外静脉侵犯（EMVI）检测的价值。
方法：这项回顾性研究的参与者在2020年10月至2022年4月期间接受了术前合成MRI检查。以10ms的单个反转时间进行SyPSIR图像重建。一名初级和高级放射科医生评估了成像质量，包括总体成像质量评分，运动伪影评分,和肿瘤和肿瘤周围血管（SItumor-vessel）之间的相对图像信号强度对比，T2WI和SyPSIR血管。使用Wilcoxon符号秩检验和双样本t检验评估两种方法之间的成像质量差异。记录T2WI和T2WI+SyPSIR血管的EMVI评分。计算受试者工作特征曲线下面积(AUC)以评价诊断性能。
结果：共评估了106例患者（35例EMVI+和71例EMVI-）。总体图像质量评分无统计学差异,运动伪影,或T2WI和SyPSIR血管之间的SI肿瘤血管（p=0.08-0.93）。在结合T2WI和SyPSIR血管时，对于初级放射科医师,病理性EMVI+诊断的AUC从0.65增加到0.88,对于高级放射科医师,AUC从0.86增加到0.96.此外，初级和高级放射科医生分析的灵敏度分别从0.40增加到0.77和0.49增加到0.86。
结论：SyPSIR血管可以提供更多信息，以提高病理性EMVI在直肠癌中的诊断效率，可能有利于临床个体化治疗。
结论：•SyPSIR血管和T2WI具有相似的成像质量。•SyPSIR船上的EMVI评估具有很高的观察员之间的协议。•SyPSIR血管有可能提高直肠癌中EMVI检测的诊断效率。
方法：这项回顾性研究的参与者在2020年10月至2022年4月期间接受了术前合成MRI检查。以10ms的单个反转时间进行SyPSIR图像重建。一名初级和高级放射科医生评估了成像质量，包括总体成像质量评分，运动伪影评分,和肿瘤和肿瘤周围血管（SItumor-vessel）之间的相对图像信号强度对比，T2WI和SyPSIR血管。使用Wilcoxon符号秩检验和双样本t检验评估两种方法之间的成像质量差异。记录T2WI和T2WI+SyPSIR血管的EMVI评分。计算受试者工作特征曲线下面积(AUC)以评价诊断性能。
结果：共评估了106例患者（35例EMVI+和71例EMVI-）。总体图像质量评分无统计学差异,运动伪影,或T2WI和SyPSIR血管之间的SI肿瘤血管（p=0.08-0.93）。在结合T2WI和SyPSIR血管时，对于初级放射科医师,病理性EMVI+诊断的AUC从0.65增加到0.88,对于高级放射科医师,AUC从0.86增加到0.96.此外，初级和高级放射科医生分析的灵敏度分别从0.40增加到0.77和0.49增加到0.86。
结论：SyPSIR血管可以提供更多信息，以提高病理性EMVI在直肠癌中的诊断效率，可能有利于临床个体化治疗。
结论：•SyPSIR血管和T2WI具有相似的成像质量。•SyPSIR船上的EMVI评估具有很高的观察员之间的协议。•SyPSIR血管有可能提高直肠癌中EMVI检测的诊断效率。
